Abstract Introduction/Objective Introduction: Cadherin-16 (CDH16), also termed kidney specific cadherin (ksp-cadherin), is a membrane-associated glycoprotein with role in the embryonal development of tubules and thyroid. Downregulation CDH16 RNA was found papillary carcinomas Methods/Case Report Methods: A set tissue microarrays containing 14,978 samples from 149 different tumor types subtypes ...

Medullary thyroid carcinomas (MTC) constitute about 5 to 7 % of thyroid neoplasms. They originate from parafollicular C-cells which can secrete adrenocorticotropic hormone (ACTH) and/or corticotropin-releasing factor (CRF) in abnormally high concentrations, potentially causing paraneoplastic Cushing's Syndrome (CS). We report on a 42-year-old male patient with a ten year history of metastatic m...

UNLABELLED Because of improvements in diagnostic technology, the incidental detection of synchronous primary tumors during the preoperative work-up of patients with esophageal cancer has increased. The aim of this study was to determine the rate and clinical relevance of synchronous neoplasms seen on (18)F-FDG PET in staging of esophageal cancer. METHODS From January 1996 to July 2004, 366 pa...

Thyroid nodules are common, affecting from 5 to 15% of the population (Tunbridge et al., 1977; Vander et al., 1968). Thyroid cancer, on the other hand, is uncommon and represents only 5% of all nodules, with an incidence in the United States of 1/10,000 inhabitants (Davies & Welch, 2006). Among thyroid neoplasms, the differentiated carcinomas (DTC) are the most frequent, and are responsible for...

Primary thyroid lymphomas (PTL) are extremely uncommon neoplasms accounting for 5% of all thyroid malignancies. There are very few small series and occasional case reports of fine needle aspiration cytology (FNAC) of PTL in literature. We present an interesting and rare case of PTL diagnosed on FNAC. FNAC is an important tool in the diagnosis of thyroid lymphoma. Journal of Cytology 2007; 24 (3...

Mature fat tissue can be found in both benign lesions and neoplasms of the thyroid gland. The pathophysiology of adipose tissue infiltration in the thyroid gland is not clear. Three cases of diffuse lipomatosis and two cases of thyroid papillary microcarcinoma containing mature fat in their stroma were diagnosed between 2002 and 2009 years. These five cases are presented in this report with a r...

Cyclooxygenase (COX), also known as prostaglandin H synthase, catalyses the formation of prostaglandins from arachidonic acid. It can be expressed in response to various stimuli, such as hormones, mitogens, cytokines, other inflammatory mediators and growth factors. The product of COX-2 activity has been implicated in carcinogenesis by promoting angiogenesis, inhibiting apoptosis, increasing ce...

Calcitonin-secreting neuroendocrine neoplasms of the lung are rare, with few cases reported in literature. Differentiating between medullary thyroid carcinoma and an ectopic source calcitonin secretion can represent a complex diagnostic conundrum for managing physicians, unnecessary thyroidectomy This manuscript reports case hypercalcitonaemia from metastatic neoplasm concurrent pathology summa...

AIMS To show that medullary carcinomas of the thyroid are morphologically indistinguishable from gut carcinoids: the value of histochemistry in their identification and differential diagnosis from metastatic carcinoid tumours to the thyroid and some follicular cell neoplasms. METHODS 15 thyroid medullary carcinomas with features of gut carcinoids were histochemically studied for the presence ...

BACKGROUND Fine needle aspiration cytology (FNAC) is a reliable and reproducible diagnostic technique for thyroid lesions with certain limitations. Computed morphometric methods have been introduced with a view to improve the diagnostic yield of thyroid aspirates. However, a review of the existing literature revealed conflicting reports regarding morphometric parameters in thyroid neoplasms. ...