The study reported here examines characteristics of weak-tie support network preference among members of health-related computer-mediated support groups. Drawing on weak-tie support network theory and socioemotional selectivity theory, participants’ age and health condition were assessed as predictors of weak ties support network preference. Relationships between the dimensions of weak-tie supp...

As a spread phenomenon, tacit knowledge integration has been attracting more attention because of the embeddedness in social activities and interactions. Our works, as a complement to previous research, investigate tacit knowledge integration based on social networks from transactive memory systems (TMS) perspective. We focus on ties dimension (expressive tie, instrumental tie, and tie strength...

Activation of endothelial cells, important in processes such as angiogenesis, is regulated by cell surface receptors, including those in the tyrosine kinase (RTK) family. Receptor activity, in turn, can be modulated by phosphorylation, turnover, or proteolytic release of a soluble extracellular domain. Previously, we demonstrated that release of soluble tie-1 receptor from endothelial cells by ...

Consensus does not exist on the level of arterial ligation in rectal cancer surgery. From oncologic considerations, many surgeons apply high tie arterial ligation (level of inferior mesenteric artery). Other strategies include ligation at the level of the superior rectal artery, just caudally to the origin of the left colic artery (low tie), and ligation at a level without any intraoperative de...

The tie gene encodes a receptor tyrosine kinase that is expressed in the endothelium of blood vessels, particularly during embryonic development and angiogenesis in adults. We have cloned and characterized the mouse tie gene and isolated the human and mouse tie promoters. The promoter activities of human and mouse tie were analyzed using luciferase reporter gene constructs in transfected cell l...

Here we present an antenna-integrated QCL which can be actively and optically modulated using light in the near infrared, creating an optical nanocircuit – coupling two different frequency antennas with a nonlinear active switching element. For our design, we chose two cross-polarized bow-tie antennas with an aligned central spot. We have used detailed FDTD simulations to choose the length of e...

Mechanistic understanding of antibiotic action can yield crucial insights that aid in the design of new antibiotics. In this issue, Mukhopadhyay et al. (2008) uncover the mechanism by which the antibiotic myxopyronin inhibits bacterial RNA polymerase, suggesting a new target region in RNA polymerase for inhibitor design.

liquid-liquid equilibrium data for the (water + lactic acid + 2-ethy-1-hexanol) ternary system in t=298.2k and p=1atm were determined and tie- lines related to equilibrium data has been drawn in the phases diagram . the reliability of the experimental tie-line data for this system was as confirmed by using the hand and othmer –tobias correlations. the tie-line data were correlated by means of t...

Diabetes is associated with impairment of angiogenesis such as reduction of myocardial capillary formation. Our previous studies demonstrate that disruption of Angiopoietin-1 (Ang-1)/Tie-2 signaling pathway contributes to the diabetes-associated impairment of angiogenesis. Protein tyrosine phosphatase (PTP) has a critical role in the regulation of insulin signal by inhibition of tyrosine kinase...