Time-restricted feeding (TRF) can reduce adiposity and lessen the co-morbidities of obesity. Mice consuming obesogenic high-fat (HF) diets develop insulin resistance hepatic steatosis, but have elevated indices long-chain polyunsaturated fatty acids (LCPUFA) that may be beneficial. While TRF impacts lipid metabolism, scant data exist regarding impact upon lipidomic composition tissues. We (1) t...

Abstract Background The circadian clock is a time keeping mechanism that drives daily rhythms in the body, including behavior and gastrointestinal digestion, inflammation, metabolism. These are endogenous to cells, they must adjust themselves cyclic environmental cues like feeding schedules light dark cycles. However, when cyclical environment chrono-disrupted (ex. shiftwork jetlag), temporal o...

Long QT syndrome type 3 (LQT3) is caused by mutations in the SCN5A-encoded Nav1.5 channel. LQT3 patients exhibit time of day-associated abnormal increases in their heart rate-corrected QT (QTc) intervals and risk for life-threatening episodes. This study determines the effects of uncoupling environmental time cues that entrain circadian rhythms (time of light and time of feeding) on heart rate ...

The mechanisms underlying CNS arousal in response to homeostatic pressures are not known. In this study, we pitted two forces for CNS arousal against each other (circadian influences vs. restricted food availability) and measured the neuronal activation that occurs in a behaviorally defined group of animals that exhibited increased arousal in anticipation of feeding restricted to their normal s...

A study was conducted to investigate the effects of methods of feeding a total mixed ration (TMR) on behavior patterns of growing Hanwoo steers. A total of 15 growing steers (13 months old) were assigned to the control (fed roughage and concentrate mix separately), TMR1 (fed restricted TMR), and TMR2 (fed TMR ad libitum) groups. Individual behaviors of steers were observed for 48 hours. Compare...