● To understand the composition and organization of extracellular matrix (ECM) in tissues and organs ● To recognize the utility of scaffolds derived from ECM in the field of tissue engineering ● To comprehend the importance of mechanical behavior and mechanical design in the use of ECM scaffolds for tissue repair ● To identify the process by which ECM scaffolds are produced ● To understand some...

Several prostheses are available to replace degenerative diseased aortic valves with unique advantages and disadvantages. Bioprotheses show excellent hemodynamic behavior and low risk of thromboembolic complications, but are limited by tissue deterioration. Mechanical heart valves have extended durability, but permanent anticoagulation is mandatory. Tissue engineering created a new generation h...

INTRODUCTION Due to the extraordinary mechanical properties of CNTs, hydroxyapatite (HAp) precipitation on functionalized carbon nanotubes (f-CNTs) suggests using CNTs as reinforcing scaffolds, in order to obtain a mechanically enhanced bone tissue. Moreover, deposition and regeneration of bone mineral phase is enhanced by the help of f-groups on CNT surface/head, even in the absence of the org...

The selection of an appropriate scaffold represents one major key to success in tissue engineering. In cardiovascular applications, where a load-bearing structure is required, scaffolds need to demonstrate sufficient mechanical properties and importantly, reliable retention of these properties during the developmental phase of the tissue engineered construct. The effect of in vitro culture cond...

Modeling the mechanical response of the brain has become increasingly important over the past decades. Although mechanical stimuli to the brain are small under physiological conditions, mechanics plays a significant role under pathological conditions including brain development, brain injury, and brain surgery. Well calibrated and validated constitutive models for brain tissue are essential to ...

INTRODUCTION Aortic heart valve dysfunction is commonly treated with replacement of the valve. To overcome the shortcomings of currently used mechanical valves, xenografts and homografts, efforts are being made to create fully autologous heart valve replacements using the concepts of tissue engineering. To this end autologous cells are seeded onto pre-shaped biodegradable scaffolds and cultured...

The mechanical characterization of adipose tissues is important for various medical purposes, including plastic surgery and biomechanical applications, such as computational human body models the simulation surgical procedures or injury prediction, example, in evaluation vehicle crashworthiness. In this context, measurement subcutaneous tissue (SAT) visceral (VAT) properties relation to subject...