introduction: esophageal squamous-cell carcinoma (scc) is one of the most common malignancies in iran. to reduce the incidence of esophageal scc, it is important to recognize the controllable risk factors and prevent them. celiac disease is widely known as a possible risk factor for esophageal scc.  thus, we decided to assess the frequency of celiac disease in esophageal scc patients in north e...

aim : the aim of this study was to determine the prevalence of celiac disease in iranian patients suffering from chronic depression or schizophrenia. background : psychiatric disorders are common in untreated celiac disease. patients and methods : two hundred iranian inpatient men with in chronic phase of depressive disorders or schizophrenia, and 200 age-matched healthy male subjects were scre...

Tissue transglutaminase is a cytosolic enzyme whose primary function is to catalyze the covalent cross-linking of proteins. To investigate the functions of this enzyme in physiological systems, we have established lines of Balb-C 3T3 fibroblasts stably transfected with a constitutive tissue transglutaminase expression plasmid. Several cell lines expressing high levels of catalytically active ti...

The nucleotide and deduced amino acid sequences of the coding regions of human and rat keratinocyte transglutaminases (protein-glutamine: amine gamma-glutamyltransferase; EC 2.3.2.13) have been determined. These yield proteins of approximately 90 kDa that are 92% identical, indicative of the conservation of important structural features. Alignments of amino acid sequences show substantial simil...

Background: Lichen planus is an autoimmune disorder and is associated with other autoimmune diseases. There is, however, little evidence of the association of oral lichen planus with celiac disease. The aim of this work was to investigate, for the first time, such an association in patients in the city of Mashhad, Iran. Methods: This case-control study was per...

OBJECTIVE Gluten sensitivity typically presents as celiac disease, a chronic, autoimmune-mediated, small-intestinal disorder. Neurological disorders occur with a frequency of up to 10% in these patients. However, neurological dysfunction can also be the sole presenting feature of gluten sensitivity. Development of autoimmunity directed toward different members of the transglutaminase gene famil...

AIM To evaluate the experience of a single coeliac center over a 10-year-observational period. MATERIAL AND METHODS Between January 2003 and December 2013 a total of 195 consecutive patients admitted with celiac disease were tested by multiple duodenal biopsies, anti-tissue transglutaminase and anti-gliadin antibodies, and baseline demographic, clinical, biological and immunological parameter...