OBJECTIVE To evaluate the cytotoxicity of poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-PDLLA) nanovesicles loaded with doxorubicin (DOX) and the photosensitizer hematoporphyrin monomethyl ether (HMME) on human hepatocellular carcinoma HepG2 cells and to investigate potential apoptotic mechanisms. METHODS PEG-PDLLA nanovesicles were simultaneously loaded with DOX and HMME (PEG-PDLLA-...

low carbon steel samples were both shot into and inoculated with titanium in order to improve mechanical properties such as strength and toughness. sem observations and x-ray analyses revealed that titanium nitride and titanium carbonitride precipitates being scattered in the ferrite substrate reduce the grain size in all as-cast, heat-treated and as-rolled cases. the growth of the grains at hi...

Standardized poly(ethylene glycol)-modified (PEGylated) liposomes, which have been widely used in research as well as in pre-clinical and clinical studies, are typically constructed using PEG with a molecular weight of 2000 Da (PEG(2000)). Targeting ligands are also generally conjugated using various functionalized PEG(2000)). However, although standardized protocols have routinely used PEG(200...

Patients with adequate intestinal function who are unable to eat may benefit from enteral tube feeding. Percutaneous endoscopic gastrostomy (PEG) is preferred when prolonged treatment is envisaged. PEG feeding will reduce morbidity and mortality in many such patients by reversing malnutrition. The increasing numbers of elderly patients with chronic diseases have resulted in an increased demand ...

Poly(ethylene glycol) (PEG) is increasingly used in clinical and experimental medicine. However, quantification of PEG and PEGylated small molecules remains laborious and unsatisfactory. In this report, we stably expressed a functional anti-PEG antibody on the surface of BALB 3T3 cells (3T3/alphaPEG cells) to develop a competitive enzyme-linked immunosorbent assay (ELISA) for PEG quantification...

Abstract In this work, two catalysts based on polyethylene glycol (PEG) containing sulfonic acid group and the −COOH of citric (CA) were synthesized. Characterization −SO 3 H functionalized PEG has been carried out using FT–IR. The acidity PEG–SO PEG–CA explored to investigate their catalytic efficiency towards eco-friendly production methyl salicylate via esterification salicylic methanol as a...

In the present work, docetaxel (DTX) and retinoic acid (RA) co-loaded micelles were developed for synergistic prostate cancer therapy. PEG-RA RA-PEG-RA synthesized subsequently used loading of DTX RA. The as prepared DTX/RA@RA-PEG-RA exhibit smaller size higher drug capacity compared to DTX/RA@PEG-RA micelles. in vitro release study shows that similar behaviours which exhibits fast RA sustained...

PURPOSE In a retrospective study, we evaluated the complications in using the motility peg system (nonsleeved and sleeved) for hydroxyapatite orbital implants in an anophthalmic socket. METHODS Drilling for motility peg placement was performed in 265 patients with hydroxyapatite implantation: nonsleeved peg system (n = 191), sleeved peg system (n = 74). A statistical analysis was performed us...

AIM To evaluate the complications associated with pegging of porous hydroxyapatite orbital implants. METHODS Complications associated with pegging were retrospectively reviewed from the charts of 100 of 133 patients with hydroxyapatite implantation from 1993 to 2000. RESULTS 48 (48%) of the 100 hydroxyapatite implanted patients who had undergone pegging were found to have problems with thei...

avoid from catch by the reticuloendothelial system (RES). It has been clarified that the prolongation of liposome circulation in the blood and passive targeting to the tumor was achieved by PEG modification of the liposomal surface. In terms of their physicochemical properties by PEG modification, many studies have examined the interaction between the prolonged circulation time of liposomes and...