at the present, many drugs are used for inhibition of uterine contractions, but the proportions of preterm labors are increasing. although magnesium sulfate is the most commonly prescribed parenteral tocolytic agent, but its optimal use has yet to be delineated. in this study a high-dose protocol for magnesium sulfate tocolytic therapy was compared with a low-dose regimen. one-hundred patients ...

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A twin gestation invariably leads to a certain extent of cervical length shortening . If this reduction is also associated with gradual dilatation internal os and various biochemical , mechanical changes in matrix can lead mid trimester pregnancy loss or preterm labour. This case report on Dichorionic Diamniotic incompetence which rescue cerclage was performed along judicious use tocolysis vagi...

The perinatal nurse, in collaboration with physicians, can use deep tendon reflexes as a powerful tool in determining the need to start, adjust, or stop magnesium infusion. Toxicity can be detected using physical manifestations as a guide. Clinical signs may be a better indicator than serum levels of tissue levels of magnesium. Whether magnesium is given to prevent seizures or for tocolysis, pa...

The aim of this paper is to review available data about drugs for preventing preterm labour. Tocolytic therapy includes β adrenergic receptor agonists, NO donors, magnesium sulphate, prostaglandin-synthase inhibitors, oxytocin receptor antagonists, calcium-channel blockers, progesterone, 17-α-hydroxyprogesterone caproate, and antibiotics. Their specific effects on myometrial contractility, thei...

background while tocolytic therapy can halt the process of delivery, some patients return before the 37th week of pregnancy with recurrence of preterm labor signs. objectives this study was designed to evaluate the efficacy of progesterone in the prolonging of gestation and reduction of neonatal complications. material and methods in a clinical trial in 2010, 110 singleton pregnant women admitt...