OBJECTIVES To measure colloid osmotic pressure in interstitial fluid (COP(i)) from human subcutaneous tissue with the modified wick technique in order to determine influence of topical application of anaesthetics, dry vs. wet wick and implantation time on COP(i). MATERIAL AND METHODS In 50 healthy volunteers interstitial fluid (IF) was collected by subcutaneous implantation of multi-filamento...

hand eczema is a common distressing skin problem. it is an immune reaction to haptens. thus, substances that inhibit immune system can be effective in the treatment of hand eczema. in this study, topical fumaric acid 5% cream is compared with topical steroid in the treatment of hand eczema. patients with hand eczema were randomly divided into two groups. one group received fumaric acid 5% in a ...

OBJECTIVE This study aims to investigate the distribution of progesterone in venous whole blood, venous serum, fingertip capillary blood, and saliva after its topical application in both cream and gel formulations. METHODS Ten postmenopausal women were randomized to receive 80 mg of progesterone cream or gel applied daily for 14 days, crossing over after a 14-day washout. On the last day of e...

objectives: burn injury is one of the most health-threatening problems in the world. malva sylvestris (m. sylvestris) flowershave a high mucilage content and are used as a remedy for cut wound and dermal infected wounds in iranian folklore medicine. the purpose of this study was to investigate the effect of m. sylvestris cream on the second degree burn injury in rats. materials and methods: fiv...

Central neuropathic pain in patients with multiple sclerosis (MS) is a common debilitating symptom, which is mostly treated with tricyclic antidepressants or antiepileptics. Unfortunately, the use of these drugs is often limited due to adverse events. We investigated the analgesic effect of topical amitriptyline 5% and 10% cream in a patient with central neuropathic pain due to MS. The analgesi...

Topical foscarnet (PFA) and acyclovir (ACV) were compared in the dorsal cutaneous guinea pig model of herpes simplex virus type 1 infection. The relative order of efficacy was PFA cream greater than ACV cream greater than ACV ointment. In vitro studies demonstrated that PFA and ACV formulated in cream vehicles penetrated through guinea pig skin 7- to 10-fold faster than did ACV in ointment.

OBJECTIVE To quantitatively examine the effects of skin rejuvenation regimens in treating photodamaged skin. METHODS Fourteen patients with photodamaged skin were considered for analysis. Skin rejuvenation regimens were as follows: (1) 10 weeks of treatment with topical 0.05% tretinoin emollient cream, (2) 10 weeks of treatment with 0.05% tretinoin emollient cream and topical ascorbic acid lo...

This study evaluated the potential of coated microneedles for improved dermal delivery of 5-aminolevulinic acid (5-ALA), which naturally gets converted by cells of the tissue in to a photosensitizer called protoporphyrin IX (PPIX). Microneedle patches containing 57 microneedles were coated with 5-ALA using an in-house developed micro-precision dip coater. The coating process was optimized to ac...

Title: A Pilot Single Centre, Double Blind, Placebo Controlled, Randomized, Parallel Study of Calmagen® Dermaceutical Cream and Lotion for the Topical Treatment of Tinea and Onychomycosis Authors: Manoj Parekh ([email protected]) Girisha Ramaiah ([email protected]) Prachi Pashilkar ([email protected]) Ranjani Ramanujam ([email protected]) Peter Johnston (peter@bi...

* Tinea pedis (athlete's foot) occurs in about 15% ofthe population * Its usual treatment is a topical antifungal applied two or three times a day for up to four weeks * Terbinafine is a synthetic allylamine antifungal with a primarily fungicidal action against dermatophytes and some other moulds and yeasts * This study shows that terbinafine 1% cream applied twice daily for a week was signific...