OBJECTIVE To assess the efficacy and safety of topical Matricaria chamomilla (Chamomile) oil in patients with knee osteoarthritis. METHOD Patients were randomized and treated with topical chamomile oil, diclofenac or placebo, 3 times/day for 3 weeks. They were allowed to use acetaminophen as analgesic. The patients were asked about their total acetaminophen use. Moreover, they were assessed i...

PURPOSE To report a case of corneal melting in a patient with fornix foreshortening being treated with reformulated generic diclofenac. METHODS Case report. RESULTS An asymptomatic 76-year old man presented with central corneal melting while being treated with reformulated generic diclofenac. This formulation did not contain the vitamin E derivative, tocophersolan, which has been felt to co...

REFERENCES 1. Szczeklik A. Adverse reactions to aspirin and nonsteroidal antiinflammatory drugs. Ann Allergy 1987;59:113-18. 2. Alkhawajah AM, Eifawai M, Mahmoud SF Fatal anaphyiactic reaction to diclofenac. Forensic Sci Int 1993;60:107-10. 3. Mescheder A, Nokhodian A, Kirch W. Anaphylactic shock as complication of Ml application of diclofenac. Arzneimitteltherapie 1993;11:237-9. 4. Romano A, P...

BACKGROUND Acute ankle sprains are common and activity limiting injuries, and topical diclofenac gel has proven efficacy in alleviating pain and restoring function. This trial aimed to compare a topical natural agent, Traumeel with topical diclofenac gel (1%) in the management of acute ankle sprain. METHODS This prospective, multicentre, randomised, blinded, active-control and non-inferiority...

Objective- To compare the effects of topical eye-drop and subconjunctival administration of diclofenac on improvement of experimental corneal alkali wound in rabbits eyes. Design- Experimental study. Animal- fifteen rabbits. Procedures- Alkali wounds were inflicted on the central corneas of 15 rabbits which we...

Actinic keratosis (AK) is an early stage of evolving skin cancer and may be classified as a squamous cell carci-noma (SCC) in situ, which originates from keratinocytes and appears on areas of skin exposed to sunlight, such as the face and arms. It is a common condition in the general population, with prevalence increasing with age and cumulative sun exposure. The American Academy of Dermatology...

pumose To compare the efficacy of topical indomethicin, dicMenac and ketorolac as pain relief following excimer laser P.R.K. &&Q&s Double masked, random&d trial involving 360 patients. Au patients rece.ived a standard regime of one of the trial dmgs and chloramphenicol ointment to be used four times daily for 3 days. Pain levels were assessed on B I ocm linear aMlogue scale prior to each instil...

Actinic keratoses (AKs) are evolving malignant cutaneous neoplasms. They are also known as solar keratosis, squamous cell carcinoma in situ-solar keratotic type, or keratinocytic intraepidermal neoplasia. Actinic keratoses can be treated by two general methods: by physical/destructive methods and with topical therapies. This article will review current and evolving topical therapeutic options f...

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed medications for the treatment of musculoskeletal disorders. Osteoarthritis is the most common form of arthritis in humans and its prevalence rises with age. Oral NSAIDs have potential associated toxicities that must be monitored for and can limit the use of these drugs in certain populations including people of older age. Top...