Lcocabastine is an extremely potent and highly selective H(1)-receptor antagonist which has been specifically developed as eye drops and nasal spray for the treatment of allergic rhinoconjunctivitis. Clinical experience to date suggests that this topical antihistamine is at least as effective as other current first-line therapeutic approaches for the treatment of this condition, including oral ...

Topical anesthesia of the airway is a necessary for awake intubation and is usually achieved using lidocaine delivered by various means. Although some experts favor the use of airway blocks, a more common approach is to use pure topical methods in combination with "spray as you go" techniques. Once the topicalization is complete, the patient should be able to easily tolerate the use of an oral ...

Background and study aims It is important to examine the pharynx during upper gastrointestinal endoscopy. Pharyngeal anesthesia using topical lidocaine is generally used as pretreatment. In Japan, lidocaine viscous solution is the anesthetic of choice, but lidocaine spray is applied when the former is considered insufficient. However, the relationship between the extent of pharyngeal anesthesia...

AIMS The study was designed to evaluate the relative bioavailability of diclofenac in plasma, subcutaneous adipose and skeletal muscle tissue after repeated topical administration using MIKA Diclofenac Spray Gel (4%), a novel formulation, and after oral dosing using VOLTAREN 50 mg enteric coated tablets. METHODS Diclofenac (48 mg) was administered topically three times daily for 3 days onto a...

BACKGROUND AND PURPOSE Previous studies have shown that either fibrin spray or tranexamic acid can reduce blood loss at total hip replacement, but the 2 treatments have not been directly compared. We therefore conducted a randomized, controlled trial. PATIENTS AND METHODS In this randomized controlled trial we compared the effect of tranexamic acid and fibrin spray on blood loss in cemented t...

conclusions in japan, 8% lidocaine pump spray contains menthol and ethanol as additives. these additives, particularly menthol, might have led to excessive mucus production, although we did not analyze the mucus secretion. introduction pulmonary collapse after intubation is common, and it is caused by a variety of factors. case presentation a 21-year-old man presented at our operation room to u...

ABSTRACT               Background and Objectives: Current medications used for the treatment of burn wounds have some side effects and disadvantages. Oral or topical administration of probiotic bacteria is thought to be useful for treatment of skin disorders. The aim of this study was to evaluate effects of spray-dried Streptococcus thermophilus on healing of second-degree burn wounds.       ...

PURPOSE To report the efficacy of Hydrosorb® versus control (water based spray) as topical treatment of grade 1-2 radiodermatitis in patients (pts) treated for early stage breast cancer (BC) with normo fractionated radiotherapy (RT). PATIENTS AND METHODS BC pts were randomized to receive either Hydrosorb® (A) or water based spray (B). The primary endpoint was local treatment failure defined a...

Topical drug delivery to poorly ventilated paranasal sinuses is challenging. Pulsating aerosols can improve the deposition of drugs like cortisol in sinuses. The current study compares effect Budesonid administered as pulsating aerosol comparison conventional nasal spray