Target of rapamycin (TOR) kinase is an evolutionarily conserved master regulator that integrates energy, nutrients, growth factors, and stress signals to promote survival and growth in all eukaryotes. The reported land plant resistance to rapamycin and the embryo lethality of the Arabidopsis tor mutants have hindered functional dissection of TOR signaling in plants. We developed sensitive cellu...

Autophagy is a critical process for recycling of cytoplasmic materials during environmental stress, senescence and cellular remodeling. It is upregulated under a wide range of abiotic stress conditions and is important for stress tolerance. Autophagy is repressed by the protein kinase target of rapamycin (TOR), which is activated in response to nutrients and in turn upregulates cell growth and ...

Während Universitäten mit ihrer Infrastruktur und Kompetenz ideale Bedingungen für den Betrieb von Tor-Knoten bieten, ist ihr Anteil am Tor-Netz erstaunlich gering. Wir berichten über unsere Erfahrungen beim zwei Exit-Knoten an geben Empfehlungen deren Betrieb.

Target of rapamycin (TOR) is a conserved regulator of cell growth and metabolism that integrates energy, growth factor, and nutrient signals. The 280-kDa TOR protein functions as the catalytic component of two large multiprotein complexes and consists of an N-terminal HEAT-repeat domain and a C-terminal Ser/Thr kinase domain. Here we describe an allelic series of mutations in the Drosophila Tor...

Helmholtz-Center DresdenRossendorf, Institute of Radiopharmaceutical Cancer Research, PET Center, Dresden, Germany Recently, we have proposed a method for on-the-fly system matrix computation where the tube-of-response (TOR) is approximated as a cylinder with constant density (TORCD) and the cubic voxels are replaced by spheres. We could show that with this model the PET image quality can be no...

Live Tor network experiments are difficult due to Tor’s distributed nature and the privacy requirements of its client base. Alternative experimentation approaches, such as simulation and emulation, must make choices about how to model various aspects of the Internet and Tor that are not possible or not desirable to duplicate or implement directly. This paper methodically models the Tor network ...

We propose in this paper a new propagation vector for malicious software by abusing the Tor network. Tor is particularly relevant, since operating a Tor exit node is easy and involves low costs compared to attack institutional or ISP networks. After presenting the Tor network from an attacker perspective, we describe an automated exploitation malware which is operated on a Tor exit node targeti...

DNA replication is a highly regulated process, with each genomic locus replicating at a distinct time of replication (ToR). Advances in ToR measurement technology enabled several genome-wide profiling studies that revealed tight associations between ToR and general genomic features and a remarkable ToR conservation in mammals. Genome wide studies further showed that at the hundreds kb-to-megaba...

BACKGROUND & OBJECTIVES El Tor Vibrio cholerae O1 carrying ctxB C trait, so-called El Tor variant that causes more severe symptoms than the prototype El Tor strain, first detected in Bangladesh was later shown to have emerged in India in 1992. Subsequently, similar V. cholerae strains were isolated in other countries in Asia and Africa. Thus, it was of interest to investigate the characteristic...