نتایج جستجو برای: tp53 codon 72 polymorphism

تعداد نتایج: 220998  

Journal: :Molecular medicine reports 2009
Márcia Portela De Melo Ana C Bittelbrunn Carlos H Menke Diego De Mendonça Uchoa Luciana Grazziotin Rossato Gustavo Lucena Kortmann Sandra Leistner-Segal

Breast cancer is the most common neoplasia as well as the main cause of cancer-related death among women, experiencing a 0.5% increase in incidence per year. The disease results from a series of mutations in the DNA development and repair genes. Approximately 50% of human carcinomas present mutations in the TP53 gene. Polymorphisms of TP53 include codon 72 containing either arginine (CGC) or pr...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2000
L M Pierce L Sivaraman W Chang A Lum T Donlon A Seifried L R Wilkens A F Lau L Le Marchand

Tobacco smoking is a strong cause of lung cancer. However, because only a small proportion of smokers develop the disease, other factors, including genetic susceptibility, may be important in determining lung cancer risk. Polymorphisms in the TP53 tumor suppressor gene and HRAS1 proto-oncogene have been associated in some studies with this cancer; we sought to replicate these associations in an...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010
Xiaoxia Hu Zhengyan Zhang Duanduan Ma Phyllis C Huettner L Stewart Massad Loan Nguyen Ingrid Borecki Janet S Rader

Host genetic variability modifies the risk of cervical cancer in women infected with oncogenic human papillomavirus (HPV). Studies have reported an association of the TP53 codon 72 arginine and cervical cancer, but the results are inconsistent. We examined the association of this single nucleotide polymorphism (SNP) in women with cervical cancer and cervical intraepithelial neoplasia grade 3, u...

Journal: :Oncology reports 2014
Jisu Oh Jong Woo Kim Bo Eun Lee Moon Ju Jang So Young Chong Pil Won Park Seong Gyu Hwang Doyeun Oh Nam Keun Kim

The microRNA (miR)-34 family is a direct transcriptional target of tumor-suppressor TP53 and loss of miR-34 function may impair TP53-mediated cell cycle arrest and apoptosis. In the present study, we investigated whether the single nucleotide polymorphisms (SNPs) rs4938723 (T>C) in the promoter region of miR-34b/c and Arg72Pro (G>C) in codon 72 of TP53 are independently or complementarily assoc...

Journal: :مجله بین المللی علوم آزمایشگاهی 0
shokouh rajabi firoozabadi seyed mostafa shiryazdi fateme keshavarz tahere nazari nasrin ghasemi

backgrounds and aims: p53 gene is regarded important in pathogenesis of different cancers. therefore, this study aimed to investigate the frequency of p53 gene codon 72 arg/pro polymorphism in women suffering from breast cancer. materials and methods: a total of 90 patients with breast cancer and 83 matched healthy control women participated in this case-control study. genomic dna was extracted...

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