Although anomalies of the trachea and oesophagus are not uncommon in paediatric practice, the case to be described is quite rare and no similar anomaly has been previously recorded at the Royal Hospital for Sick Children, Glasgow. Briefly, the condition is one of atresia of the larynx, partial absence of the trachea and a fistulous connexion between the oesophagus and the trachea. A point of co...

BACKGROUND Surgery remains the main treatment for locally advanced thyroid cancers invading the trachea, esophagus, and recurrent laryngeal nerve. However, extensive resection of such tumors can sometimes involve difficulties and may result in the deterioration of the patient's quality of life. The surgeon should consider not only the patient's prognosis but also the preservation of postoperati...

squamous metaplasia. This change was chiefly in the posterior muscular wall of the trachea, but frequently extended to the lateral and anterior walls of the trachea, and into the bronchi. It is suggested that the primary localization to the muscular trachea is related to the embryology of the congenital deformity, and that secondary factors such as acute infection and oxygen therapy may extend ...

Advances in surgical technique and in anaesthesia have made possible a more radical attack on lesions affecting the trachea. Although the number of patients presenting with such a tracheal lesion is small, it is important that they should be treated adequately. Tracheal reconstruction is indicated both for benign and for malignant neoplasms, most of which are found to arise in the lower third. ...

Surgical procedures on the trachea have only been undertaken within the past 50 years. Knowing the unique blood supply of the trachea and how to reduce tension on any anastomosis are key to a successful outcome. Tracheal conditions requiring surgery usually present with shortness of breath on exertion, and preoperative evaluation involves computed tomography and rigid bronchoscopy. Tracheal res...

Bronchial anastomosis is now a practicable procedure. It was first successfully performed in dogs and reported by Jackson, Lafkin, Tuttle, and Hampton (1949), and in that same year Tuttle described the first successful anastomosis in the human subject after accidental division of a major bronchus. Later reports followed (Mathey and Oustrieres, 1951), and tne healing properties of the bronchial ...

In respiratory carcinogenesis studies in Syrian golden hamsters, trachea! epithelium is a target tissue for the development of tumors induced by polynuclear aromatic hydrocarbon carcinogens. For evaluation of the capacity for metabolism of these carcinogens in this target tissue, the conversion of the carcinogen benzo(a)pyrene (BP) to polar products was studied in trachea! organ cultures and in...

The ability of the M2 muscarinic receptor to mediate an inhibition of the relaxant effects of forskolin and isoproterenol was investigated in guinea pig ileum and trachea. In some experiments, trachea was first treated with 4-diphenylacetoxy-N-methylpiperidine (4-DAMP) mustard to inactivate M3 receptors. The contractile response to oxotremorine-M was measured subsequently in the presence of bot...