Among the many existing hearing problems, there are those that need to be corrected through the replacement of the ossicles of the middle ear with a prosthesis. The type of the prosthesis used in the rehabilitation of the middle ear, total ossicular replacement prosthesis (TORP) or a partial ossicular replacement prosthesis (PORP) depends of the level of the ossicular impairment [1,2]. In the p...

The perforations of the tympanic membrane maybe of traumatic origin or due to chronic suppurative otitis media. If the perforations fail to heal conservatively, they require surgical closure. Autologous graft materials have stood the test of time in repairing tympanic membrane perforations. In our tertiary care institution we conducted a prospective randomized control trial on 50 subjects to ev...

objective articular cartilage as an avascular skeletal tissue possesses limited capacity to heal. on the other hand, it is believed that the regeneration capacity of each tissue is largely related to its stem cell contents. little is known about the presence of mesenchymal stem cells in articular cartilage tissue. this subject is investigated in the present study. materials and methods articula...

Introduction: The eradication of the middle ear disease is mentioned as the fundamental principle of tympanoplasty. The presence of some factors related to patient or disease itself forces the physician to classify the chronic ear disease as high-risk perforations. The aim of this study was to present a tri-layer tympanoplasty technique and its otological and audiological outcomes in the ...

background tissue engineering is used for the treatment of many diseases, and the ideal cell source for cartilage tissue engineering is chondrocytes. the main limitation of chondrocyte is the low number of cells in cartilage tissue engineering. this study investigated a suitable cell source with high proliferation rate to obtain a large number of chondrocytes. methods adult cartilage tissue sam...