t cells have been identified as key players in the pathogenesis of type 1 diabetes. however, the exact role of t-cell subpopulations in this pathway is presently unknown. the purpose of this study was to assess the expression pattern of two lineage-specifying transcription factors gata - 3 and t - bet , which are important in t helper type 1 (th1) and th2 cell development , respectively. gene e...

The majority of the bioactives under investigation were predicted to target TNF receptor-associated factor 5 in Janus kinase/signal transducers and activators transcription pathway. Similarly, druglikeness prediction identified vitexilactone possess highest score, i.e., 0.88. Furthermore, proteins targeted pathway also regulate multiple pathways, ErbB, AGE-RAGE, NF-kappa B, Measles, insulin, mT...

t cells have been identified as key players in the pathogenesis of type 1 diabetes. however, the exact role of t-cell subpopulations in this pathway is presently unknown. the purpose of this study was to assess the expression pattern of two lineage-specifying transcription factors gata - 3 and t - bet , which are important in t helper type 1 (th1) and th2 cell development , respectively. gene e...

Background: SALL2 is a developmental transcription factor involved in the regulation of cell proliferation, migration, and survival. Massive data analyses cancer versus normal tissues indicate that mRNA significantly decreased colorectal (CRC), type characterized by hyperactivation Wnt pathway. Interestingly, our previous ChIP-seq suggested regulates genes associated with pathway, including neg...

Bacillus thuringiensis Berliner as a biological control agent can play a crucial role in the integrated management of a wide range of plant pests and diseases. B. thuringiensis is expected to elicit plant defensive response through plant recognition of microbe-associated molecular patterns (MAMPs), however, there is little information on the molecular base of induced systemic ...

a proteomic approach was conducted to further understand the mechanism of plant responses to salinity in hordeum bulbosom. three-week-old seedlings were treated with 300 mm of nacl for 21 days. total proteins of fourth leaf were extracted and separated by two-dimensional gel electrophoresis. more than 500 protein spots were reproducibly detected, including 46 spots that were up-regulated and 16...

Background and Objective: Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is a class II membrane glycoprotein that binds to insulin α receptor and can interfere in insulin signaling pathway. Transcription factor-7-like 2 (TCF7L2) is a transcription factor which plays a critical role in pancreatic β cell activity. ENPP1 and TCF7L2 gene polymorphisms may have functional role in suscep...