background: blood donation safety is one of the basic goals of the organization of blood transfusion in the world. self-exclusion and failed options are additional screening tests to routine diagnostic tests which is performed to detect the transmitted infection through blood or blood products. the purpose of this study was to investigate the efficacy of these systems on the improvement of bloo...

The residual risk of transfusion transmitted infection (TTI) had been decreased greatly since the donor screening methods, especially the nucleic acid testing (NAT), were introduced. NAT can shorten the period between infection and detection (window period) to several days after infection [1]. However, transfusion safety still faces challenges due to limitations of test sensitivity and more imp...

Dear Editor, The risk of transfusion-transmitted hepatitis C virus (HCV) infection was the greatest in people with haemophilia (PWH) before identification and testing for this virus became available in 1987. After introduction of HCV screening and virucidal measures post 1987, this risk significantly reduced in the developed countries (1.8%). 1 However, in resource poor settings, the risk still...

A spectrum of blood-borne infectious agents is transmitted through transfusion of infected blood donated by apparently healthy and asymptomatic blood donors. The diversity of infectious agents includes hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency viruses (HIV-1/2), human T-cell lymphotropic viruses (HTLV-I/II), Cytomegalovirus (CMV), Parvovirus B19, West Nile Virus (...

BACKGROUND Malaria is the most important transfusion-transmitted infection (TTI) in worldwide after viral hepatitis and human immunodeficiency virus (HIV) infection. The main objective of the present study was to review and evaluate the transmission of malaria via blood transfusion in Iran. METHODS A literature search was done without time limitation in the electronic databases as follows: Pu...

Blood transfusion history dates back about 200 years. The credit of first successful human to human blood transfusion goes to Dr. James Blundell, an obstetrician, who successfully transfused 8 oz (227 ml) of blood to a patient of postpartum hemorrhage in 1818 (Mahmud, 2009). In developing countries, the prevalence of transfusiontransmitted disease is much higher and far from attaining a “zero r...

In sub-Saharan Africa, transfusion-transmitted human immunodeficiency virus (HIV) infection persists, particularly among women and children, who receive most blood transfusions. Providing technical and financial assistance to national blood transfusion services to increase the adequacy of blood collections and to prevent transfusion-transmitted HIV infection continues to be a priority under the...