INTRODUCTION The aim of this study was to determine the diagnostic value of urine nuclear matrix protein 22 (NMP22) level in detection of transitional cell carcinoma (TCC) of the bladder. MATERIALS AND METHODS A total of 76 patients with newly-diagnosed or recurrent TCC and 75 controls without urinary tract disorders participated in this study. A urine sample was obtained for measurement of t...

Bladder cancer is a significant health problem and is the fourth most common malignancy in the Western world. Histologically, transitional cell carcinoma (TCC) is the most common subtype and represents nearly 90% of all bladder cancers. Mutations of the tumour suppressor gene p53 are the most frequent genetic alteration found in human cancers, including urinary bladder carcinoma. Numerous studi...

BACKGROUND Majority of bladder cancer deaths are caused due to transitional cell carcinoma (TCC) which is the most prevalent and chemoresistant malignancy of urinary bladder. Therefore, we analyzed the role of Sperm associated antigen 9 (SPAG9) in bladder TCC. METHODOLOGY AND FINDINGS We examined SPAG9 expression and humoral response in 125 bladder TCC patients. Four bladder cancer cell lines...

The presence of carcinoma in situ (CIS) lesions in the urinary bladder is associated with a high risk of disease progression to a muscle invasive stage. In this study, we used microarray expression profiling to examine the gene expression patterns in superficial transitional cell carcinoma (sTCC) with surrounding CIS (13 patients), without surrounding CIS lesions (15 patients), and in muscle in...

A 39 year old Caucasian male presented with a 10 day history of visible painless haematuria. He had one previous episode of haematuria ten months prior to this following ozone therapy for Lyme's disease. His past medical history included alopecia and chronic fatigue syndrome. He took no regular medications. There were no risk factors for transitional cell carcinoma (TCC) of the bladder. An ultr...

This study described high-field magnetic resonance imaging (MRI) and computed tomography (CT) characteristics of muscle-invasive bladder transitional cell carcinoma (TCC) in two dogs. Ultrasonography revealed a urinary bladder mass with ambiguous result about invasion to the muscular layer. Contrast-enhanced CT showed that the bladder wall in which the mass was attached was more intensely enhan...

• In this case, we are presented with a 70 year old male retired insurance executive, 35 pack-year smoker, with no other environmental exposure risks, but with a history of lithotripsy for renal stones, and with non-invasive papillary transitional cell carcinoma (TCC) in the right ureter and bladder (at least 2 sites). The patient presented with hematuria, right flank pain, urinary urgency and ...

introduction bladder cancer is the most common malignancy in elderly people and most bladder cancers are transitional cell carcinomas (tcc). bladder pathology is usually investigated visually by cystoscopy and this technique can represent different conditions ranging from simple inflammation to flat cis. however, biopsies must be taken from the suspected area to obtain diagnostic information. t...

OBJECTIVE To assess the demographic and clinico-pathological trends, as well as the management options of adult patients with primary malignant renal tumors over 6 years. METHODS From July 2003 - July 2009, 55 adult patients with primary malignant renal tumors were treated in two teaching hospitals (Jordan University Hospital in Amman - Jordan and Al-Jumhory Teaching Hospital in Mosul - Iraq)...

BACKGROUND To determine the association of human papillomavirus infection (HPV) and transitional cell carcinoma (TCC). METHODS Using polymerase chain reaction, fifty-nine bladder tissue specimens of patients with transitional cell carcinoma of bladder compared with 20 bladder samples of cases with non-neoplastic disorders. RESULTS Male to female ratio was similar in the two groups (50/9 vs....