نتایج جستجو برای: transporter
تعداد نتایج: 49293 فیلتر نتایج به سال:
Abstract L-type amino acid transporter 2 (LAT2) is a Na + -independent neutral transporter, whose function regulation system remains unclarified. Since protein kinase C (PKC) known to regulate the functions of various transporters, we investigated whether human LAT2 (hLAT2) regulated by PKC. In mouse proximal tubule S2 cells, hLAT2 transport activity was upregulated PKC activation. However, fou...
Accumulating evidence has demonstrated that the sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 have a role in the modulation of pain transmission at the spinal level through chloride regulation in the pain pathway and by effecting neuronal excitability and pain sensitization. The present study aimed to investigate the analgesic effect of the specific sodium-p...
Astrocytes serve essential roles in human brain function and diseases. Growing evidence indicates that astrocytes are central players of the feedback modulation excitatory Glu signalling during epileptiform activity via Glu-GABA exchange. The underlying mechanism results increase tonic inhibition by reverse operation astroglial GABA transporter, induced Glu-Na+ symport. GABA, released from astr...
BACKGROUND The ATP-binding cassette (ABC) transporter gene superfamily is ubiquitous among extant organisms and prominently represented in plants. ABC transporters act to transport compounds across cellular membranes and are involved in a diverse range of biological processes. Thus, the applicability to biotechnology is vast, including cancer resistance in humans, drug resistance among vertebra...
The dopamine transporter mediates reuptake of dopamine from the synaptic cleft. The cellular mechanisms controlling dopamine transporter levels in striatal nerve terminals remain poorly understood. The dopamine transporters contain a C-terminal PDZ (PSD-95/Discs-large/ZO-1) domain-binding sequence believed to bind synaptic scaffolding proteins, but its functional significance is uncertain. Here...
Background Neuroticism is a major risk factor for affective disorders. This personality trait has been hypothesized to associate with synaptic availability of the serotonin transporter, which critically controls serotonergic tone in the brain. However, earlier studies linking neuroticism and serotonin transporter have failed to produce converging findings. Because sex affects both the serotoner...
BACKGROUND Several lines of evidence implicate abnormal serotonergic function in suicidal behavior and completed suicide, including low serotonin transporter binding in postmortem studies of completed suicide. We have also reported low in vivo serotonin transporter binding in major depressive disorder (MDD) during a major depressive episode using positron emission tomography (PET) with [(11)C]M...
Engineered peptide based biocompatible, siRNA transporter can transfect primary and TNBC cells with efficient long-term gene silencing. Nanocomplex silencing Notch1 exhibits synergistic interaction metformin amplifies anticancer therapy.
Abstract In traditional parcel delivery operations, customers determine locations and, hence, the performance of a transporter. We exploit this idea and show that can improve efficiency transporter by giving latter flexibility in choosing locations. Two possible policies to enable are presented evaluated. The first policy, conceptually similar roaming vehicle routing, is related presence altern...
Cancer cells are metabolically reprogrammed to support their high rates of proliferation, continuous growth, survival, invasion, metastasis, and resistance cancer treatments. Among changes in cell bioenergetics, the role glutamine metabolism has been receiving increasing attention. Increased glutaminolysis is associated with increased expression membrane transporters that mediate cellular uptak...
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