Ewing sarcoma (ES) is the second most common bone tumor in children and young adults, with dismal outcomes for metastatic and relapsed disease. To better understand the molecular pathogenesis of ES and to identify new prognostic markers, we used molecular inversion probes (MIPs) to evaluate copy number alterations (CNAs) and loss of heterozygosity (LOH) in formalin-fixed paraffin-embedded (FFPE...

Frequency potentiation of contractile function is a major mechanism of the increase in myocardial performance during exercise. In heart failure (HF), this positive force-frequency relation is impaired, and the abnormal left ventricular (LV)-arterial coupling is exacerbated by tachycardia. A myofilament Ca(2+) sensitizer, levosimendan, has been shown to improve exercise tolerance in HF. This may...

In this research work an attempt has been made to minimize flank wear of uncoated carbide inserts while machining AISI 1045 steel by finite element analysis. Tool wear is the predominant factor that causes poor surface finish and is responsible for the dimensional accuracy of the machined surface. The quality of component produced decides the effectiveness and competitiveness of any manufacturi...

The proliferation rate and differentiation state were investigated in porcine inner cell masses (ICMs) and epiblasts in vitro. ICMs isolated from early blastocysts (Day 7 of pregnancy) and epiblasts isolated from preelongated blastocysts (Day 11 of pregnancy) were cultured for up to 5 days in the presence of human leukemia inhibitory factor (hLIF) (1000 U/ml). The proliferation rate was evaluat...

Dravet syndrome (DS) is an epileptic encephalopathy related mainly to mutations in the SCN1A gene, encoding for neuronal sodium channels. Patients with DS have a high risk of sudden unexpected death in epilepsy (SUDEP). In this study we investigated whether patients with DS present abnormalities in electrical and autonomic cardiac function. To this aim we assessed ventricular repolarization and...

Fractionated excretory/secretory products (ES) of adult Haemonchus contortus were evaluated as protective antigens. The proteins were successively eluted from a Thiol Sepharose column using 25 mM cysteine followed by 25 mM Dl-dithiothreitol (DTT). Sheep were vaccinated three times and challenged with 5000 third stage infective larvae (L3) of H. contortus. Highest level of protection was found i...

Background: There are various methods to read out responses of a polymer-gel dosimeter, among which the Magnetic Resonance Imaging (MRI) technique is the most common one. Optimizing imaging protocols can have significant effect on the sensitivity and the dose resolution of polymer gel dosimeters. This study has investigated the effects of the number of echoes (NOE) and the echo time spacing (ES...

Background: This retrospective study compared pregnancy outcomes from single embryo transfer (SET) with multiple embryo transfer (MET) in too young (≤25 years) and young (>25 years) infertile patients. Materials and Methods: Data from infertile patients who referred for ART treatment to Yazd infertility center during 1992 to 2012 were studied retrospectively. Records of patients with SET or MET...

Background: Epileptic spasms (ES) are a devastating seizure type with poor neurodevelopmental outcome; 1/3 resistant to treatment first line therapies. Recently attention has been drawn the ketogenic diet (KD) as potentially effective therapy, though data regarding optimal time of initiation, and its sustained effectiveness, lacking. Methods: Retrospective chart review all patients ES treated K...