A series of new clubbed aryl oxadiazole-1,2,4-triazine derivatives (6a-l) were designed and synthesized using appropriate chemical routes. The structures to have the required structural elements for any compounds be potential anticonvulsant. Preliminary screening anticonvulsant activity was performed maximal electroshock seizure (MES), subcutaneous pentylenetetrazole-induced (scPTZ) behavioral ...

Herein, we report a new method of synthesis N-acylureas (E1–5) via reaction dibenzoylhydrazine carboxamide (N,2-bis(4-methoxybenzoyl)hydrazine-1-carboxamide) (C) and various benzylamines. Preparation was performed by the treatment 5,6-diaryl-3-methylthio-1,2,4-triazine (B) with Oxone which leads to oxidation triazine ring cleavage in high yield (82%). Five benzylamine derivatives containing dif...

http://www.revistadechimie.ro 964 It is established that analogues of natural nucleobases and nucleosides, containing nitrogen atoms have good antimetabolite [1, 2], antiviral, antibacterial [3, 4] antitumor and antimetastatic properties [5]. One of the first compounds obtained, exhibiting good antitumor and antimetabolite activity is 6-azauridine, an analogue of 6azauracil [2]. In recent years...

An efficient method for the synthesis of 1,3,5-triazines by NIS-catalyzed oxidative cyclization of alcohols with amidines has been developed. The reaction works smoothly under transition-metal free and phosphine-free conditions to afford a wide range of 1,3,5-triazine derivatives in moderate to good yields. The synthetic methodology was achieved via in situ oxidation of alcohols to aldehydes.

The NCNN group is an essential part of various heterocycles bearing high biological activities. 1,2,4-Triazines and their condensed derivatives found applications as pharmaceuticals and in agriculture. For example vardenafil ñ phosphodiesterase inhibitor, is useful in the treatment of male erectile dysfunctions (1), apazone exhibit anti-inflammatory and analgesic actions (2), lamotrigine is use...