نتایج جستجو برای: tricarboxylic acid
تعداد نتایج: 747504 فیلتر نتایج به سال:
Here we analyzed whether the anti-neoplastic effect of carnosine, which inhibits glycolytic ATP production, can be antagonized by ATP production via oxidative phosphorylation fueled by pyruvate. Therefore, glioblastoma cells were cultivated in medium supplemented with glucose, galactose or pyruvate and in the presence or absence of carnosine. CPI-613 was employed to inhibit the entry of pyruvat...
Metabolites and enzyme activities involved in energy metabolism in Taenia solium cysticerci were determined systematically in vivo in order to illustrate the principles of variation of energy metabolism. Metabolites and enzymes determined included GLC, LAC, PEPCK, PK, LDH, SDH, ICD, XOD, ME, GDH, FR, ATPase, ACP, AKP, G6Pase and FE. The results showed that transport of substances, anaerobic gly...
The current concept of fatty acid metabolism involves the formation of acetyl CoAl and the condensation of acetyl CoA with oxalacetate upon entrance into the tricarboxylic acid cycle. Therefore, a sufficient amount of oxalacetic acid is necessary for the complete oxidation of fatty acids via the tricarboxylic acid cycle, and, if sufficient oxalacetic acid is not present., ketosis results. Previ...
Background: One of the main sunfl ower diseases is the white mold Sclerotinia sclerotiorum. The oxalic acid (OA), which is one of the main pathogenicity factors of this fungus, beside the direct toxicity on the host, has other functions such as the disruption of the cell wall and chelating out the calcium ions.Objectives: Regarding the importance of this disease, it is im...
The transepithelial electrical potential difference across the isolated midgut of Bombyx mori larvae is dependent on the presence of potassium and is unaffected by the addition of hexoses to perfusion media, whereas it is enhanced by alanine, aspartic acid, glutamic acid and the corresponding 2oxoacids, glutamine and malate. The midgut enzyme profile indicates that the substrates for the tricar...
Enzymatic analyses of Bacillus thuringiensis extracts suggest that a modified Krebs tricarboxylic acid cycle (without alpha-ketoglutarate dehydrogenase) can operate during sporulation in conjunction with the glyoxylic acid cycle and the gamma-aminobutyric acid pathway.
In a previous publication (1) the significance of lactic and citric acid synthesis by bone was discussed. Acid formation by other connective tissues such as cartilage (2, 3) cornea (4), and lens (5-7) has also been demonstrated. The presence of the glycolytic enzymes in skin and the formation of lactic acid have been demonstrated by several investigators (8-12). Although Dickens (13) found that...
Isolated rat hepatocytes were cultured in a modified HI-WO/BA medium for 16 h. In the following 24 h oleate or oleate plus ethanol was added to the medium. After this period the medium was changed again and the cultures were further incubated with [1-14C]oleate alone or with [1-14C]oleate plus ethanol for 6 h. This allowed a comparison of effects of short-term (6 h) and long-term (24 + 6 h) exp...
BACKGROUND Diabetes-associated cardiac dysfunction is associated with mitochondrial dysfunction and oxidative stress, which may contribute to left ventricular dysfunction. The contribution of altered myocardial insulin action, independent of associated changes in systemic metabolism, is incompletely understood. The present study tested the hypothesis that perinatal loss of insulin signaling in ...
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