The Laplacian spread of a graph is defined to be the difference between the largest eigenvalue and the second smallest eigenvalue of the Laplacian matrix of the graph. In this paper, we investigate Laplacian spread of graphs, and prove that there exist exactly five types of tricyclic graphs with maximum Laplacian spread among all tricyclic graphs of fixed order.

An improved multistep synthesis of tricyclic α-cyanopyrrolidine from camphor is presented. The synthesis was carried out by maintaining the cyano group in the form of an amide and its regeneration after the completion of the necessary chemical transformation of a particular functional group. The tricyclic α-cyanopyrrolidine prepared was used to synthesize two novel compounds of DPP4 (Dipeptidyl...

A 22 year old woman was admitted with amitriptyline overdose. Twenty six hours later she developed acute myocardial infarction. Cardiotoxic effects of tricyclic antidepressants are discussed and the importance of considering myocardial infarction as a complication of tricyclic antidepressant overdose is emphasized.

Tricyclic antidepressants (TCAs) may have dangerous cardiac effects in overdose. ECG is useful as both a screening tool for tricyclic antidepressant exposure and as a prognostic indicator. TCA overdose may produce various ECG changes. We report a case of Dothiepin overdose resulting in Brugada like pattern including RBBB which resolved spontaneously.

In this paper, we determine the tight upper bound for the number of matchings of connected n-vertex tricyclic graphs. We show that this bound is 13fn−4+16fn−5, where fn be the nth Fibonacci number. We also characterize the n-vertex simple connected tricyclic graph for which the bound is best possible.

This review, together with Part 1 (Gun. Chem. 26: 5-17, 1980), summarizes progress in measurement of tricyclic antidepressants in biological fluids and the application of the methodology to Clinical practice. For many of the older drugs and for all of the new-generation antidepressants, further studies are required to delineate the precise relationship between plasma concentration and clinical ...