Cholestyramine feeding of rats increased the rate of palmitate and glycerol incorporation into triacylglycerols of isolated hepatocytes. Concomitantly an increase of fatty-acid binding by hepatic cytosolic proteins was observed, which could be attributed to an elevation of the content of the fatty-acid-binding protein (Mr 12000). The involvement of this protein in cholesterol, bile-acid and tri...

Fish oil is a potent triglyceride (TG)-lowering agent in humans. The goal of the present study was to assess the contribution of decreased triglyceride synthesis and of apoE in mediation of the triglyceride-lowering effect of fish oil. To this end, apoE-deficient mice and wild-type control mice were supplemented with either coconut oil, sunflower oil, or fish oil (20% wt/wt) for 2 weeks. Compar...

PURPOSE OF REVIEW Elevated plasma triglyceride and reduced HDL concentrations are prominent features of metabolic syndrome and type 2 diabetes. Individuals with Tangier disease also have elevated plasma triglyceride concentrations and very low HDL, resulting from mutations in ATP-binding cassette transporter A1 (ABCA1), an integral membrane protein that facilitates nascent HDL particle assembly...

background   lipoprotein lipase activity can be increased by clofibrate. clofibrate is used to reduce serum triglyceride level in adults. the aim of this study was to determine the effect of clofibrate on serum triglyceride and cholesterol level after administration of intravenous lipid in very low birth weight neonates. method in a randomized double blind placebo – controlled study, 60 very lo...

in india, the occurrence of diabetes mellitus is on increase and needs to be addressed properly. herbal remedies are considered most suitable for the management of type 2 diabetes due to their traditional acceptability and availability, low costs, and fewer side effects. traditionally bauhinia tomentosa l. (family- fabaceae) is used in the treatment of diabetes in india. aqueous extract and alc...

Hypertriglyceridemia is an independent risk factor for atherosclerosis. This risk is most likely due to accumulation of circulating triglyceride rich lipoproteins with heterogeneous particles. The identification and characterization of these triglyceride rich lipoproteins is important to detect abnormality of triglyceride metabolism. In the present study, we developed a new method that combines...

1. Studies were carried out to test the assumptions involved in the calculation of free fatty acid (FFA) and triglyceride transport rates from the plasma radioactivity curves after the intravenous administration of labelled fatty acid or of pre-labelled lipoprotein triglyceride. 2. Plasma FFA equilibrates reversibly with the interstitial lymph. This makes it necessary to use either a pulse inje...

We have studied the accretion of lipids in growing mice. We measured the rates of synthesis and degradation of triglycerides in epididymal fat pads of mice maintained for 44 days on a low-fat, high-carbohydrate diet (I) or a high-fat, low-carbohydrate diet (II). 2H2O was added to the drinking water for 14 days. Rates of incorporation/washout of 2H to/from C1 of triglyceride-glycerol showed that...

Fig. 1. Triglyceride transport in the blood. Triglycerides are synthesized in either the intestine or liver. Chylomicrons are secreted into the lymph and then enter the circulation via the superior vena cava. VLDL are directly secreted into the blood. Both particles are metabolized via their interaction with lipoprotein lipase on the luminal surface; a reaction that coverts the triglyceride int...

despite the fact that most people are worried about having high cholesterol levels, low cholesterol may actually be associated with adverse behavioral effects such as aggression and depression. the aim of this survey was to show whether there was a significant relationship between cholesterol and triglyceride with depression. the level of cholesterol and triglyceride was measured in 80 depresse...