Although fasting induces hepatic triglyceride (TG) accumulation in both rodents and humans, little is known about the underlying mechanism. Because parasympathetic nervous system activity tends to attenuate the secretion of very-low-density-lipoprotein-triglyceride (VLDL-TG) and increase TG stores in the liver, and serum cholinesterase activity is elevated in fatty liver disease, the inhibition...

Reingold, Jason S., Jonathan M. McGavock, Shaheen Kaka, Tommy Tillery, Ronald G. Victor, and Lidia S. Szczepaniak. Determination of triglyceride in the human myocardium by magnetic resonance spectroscopy: reproducibility and sensitivity of the method. Am J Physiol Endocrinol Metab 289: E935–E939, 2005. First published June 21, 2005; doi:10.1152/ajpendo.00095.2005.—The primary aim of this invest...

Triglyceride (TG), a water-insoluble energy-rich lipid, is secreted by the liver as part of very low density lipoproteins (VLDLs) to supply energy to extrahepatic tissues. Overproduction of VLDL is associated with increased risk of cardiovascular heart disease; this has renewed an interest in factors that affect hepatic TG production. The TG production rate is determined by measuring temporal i...

INTRODUCTION Obesity, insulin resistance, and metabolic syndrome are escalating problems in developed and developing countries. High plasma triglyceride (TG) levels are commonly encountered in clinical practice; 30% of the adult US population has a TG level above 150mg/dL. Hypertriglyceridemia is perceived to be associated with increased risk of coronary heart disease (CHD) in many epidemiologi...

BACKGROUND The microsomal triglyceride transfer protein (MTP) is involved in hepatic and intestinal apoB secretion. We studied the effect of the functional MTP-493G/T polymorphism on fasting and postprandial lipoproteins in patients with familial combined hyperlipidemia (FCH) before and after treatment with atorvastatin. METHODS Eight FCH heterozygote carriers of the rare -493T allele were co...

Hypertension is a global health issue because of its high prevalence and association with increased risk cardiovascular disease. This work evaluated the anti-dyslipidemic potential aqueous extract avocado seed (APE) (50 – 100 mg/kg) in adult male wistar rats. Twenty-five rats were used for this divided into five groups 5 each (n= 5). Group 1 (normal control), group 2 (cyclosporine alone), 3 + m...

Excessive secretion of triglyceride-rich very low-density lipoproteins (VLDL-TG) contributes to diabetic dyslipidemia. Earlier studies have indicated a possible role for the hypothalamus and autonomic nervous system in the regulation of VLDL-TG. In the current study, we investigated whether the autonomic nervous system and hypothalamic neuropeptide Y (NPY) release during fasting regulates hepat...

Rad is a low molecular weight GTPase that is overexpressed in skeletal muscle of some patients with type 2 diabetes mellitus and/or obesity. Overexpression of Rad in adipocytes and muscle cells in culture results in diminished insulin-stimulated glucose uptake. To further elucidate the potential role of Rad in vivo, we have generated transgenic (tg) mice that overexpress Rad in muscle using the...

Background/Aim: Non-alcoholic fatty liver disease (NAFLD) refers to the accumulation of hepatic steatosis not due to excess alcohol consumption.It is the most common liver condition in the world.The prevalence of NAFLD is up to 30% in developed countries and nearly 10% in developing nations. The aim of this study is to assess serum alpha-fetoprotein triglyceride, and total cholesterolamong Suda...