Diabetes Mellitus (DM) is recognized as a critical priority because of its epidemic nature. Successful diabetes treatment not yet established and nowadays, considered global problem. Recent medications have proved to be complete treating agents because, until now no one had completely cured diabetes. Current antidiabetic drugs many undesirable side effects. So, an alternative therapy required. ...

We investigated whether niacin-related compounds had radical-scavenging activity by electron spin resonance methods. Many compounds, but not trigonelline, had radical-scavenging activity against hydroxyl radicals. However, for the nitric oxide radical and 1,1-diphenyl-2-picrylhydrazyl radical, only nicotinic acid hydrazide and isonicotinic acid hydrazide had scavenging activities. These results...

fenugreek (trigonella foenum-graecum l.), wild or cultivated, is widely distributed throughout the world and belongs to the fabacecae family. it is an old medicinal plant and has been commonly used as a traditional food and medicine. fenugreek is known to have hypoglycemic, and hypocholesterolaemic, effects. recent research has identified fenugreek as a valuable medicinal plant with potential f...

Slightly depressed growth and fatty livers were observed in animals fed moderate amounts of nicotinamide, while larger quantities completely inhibited growth (1,2). The fatty livers were found to be susceptible to the action of choline, while only methionine was found to alleviate the growth inhibition. These phenomena were ascribed to the forced synthesis of trigonelline from nicotinamide with...

Mathematical models based on chemometric analyses of the coffee beverage sensory data and NIR spectra of 51 Arabica roasted coffee samples were generated aiming to predict the scores of acidity, bitterness, flavour, cleanliness, body and overall quality of coffee beverage. Partial least squares (PLS) were used to construct the models. The ordered predictor selection (OPS) algorithm was applied ...

This study aimed to examine the effect of pea fiber (PF) and wheat bran fiber (WF) supplementation in rat metabolism. Rats were assigned randomly to one of three dietary groups and were given a basal diet containing 15% PF, 15% WF, or no supplemental fiber. Urine and plasma samples were analyzed by NMR-based metabolomics. PF significantly increased the plasma levels of 3-hydroxybutyrate, and my...

SCOPE In order to validate the in vivo function of putatively healthy molecules in foods, human intervention studies are required. As the subject's compliance concerning intake or abstinence of a given food is considered mandatory to be monitored by biomarkers, the objective was to identify analytical markers for coffee consumption. METHODS AND RESULTS Urine samples collected from coffee drin...