Nano-sized multinuclear ruthenium complexes have rapidly emerged as promising therapeutic candidates with unique anticancer activities. Here, we describe the coordination-driven self-assembly and anticancer activities of a set of three organometallic tetranuclear Ru(II) molecular bowls. [2+2] Coordination-driven self-assembly of 3, 6-bis(pyridin-3- ylethynyl) phenanthrene (bpep) (1) and one of ...

Central to embryonic development is the generation of molecular asymmetries across fields of undifferentiated cells. The Drosophila wing imaginal disc provides a powerful system with which to understand how such asymmetries are generated and how they contribute to formation of a complex structure. Early in development, the wing primordium is subdivided into a thin layer of peripodial epithelium...

Many English noun pairs suggest an almost limitless array of semantic interpretation. A fruit bowl might be described as a bowl for fruit, a bowl that contains fruit, a bowl for holding fruit, or even (perhaps in a modern sculpture class), a bowl made out of fruit. These interpretations vary in syntax, semantic denotation, plausibility, and level of semantic detail. For example, a headache pill...

A bowl-shaped nitrogen-doped nanographene composed of a pyrrolo[3,2-b]pyrrole core substituted with six arene rings circularly bonded one another undergoes bowl-to-bowl inversion low barrier. This resembles that an umbrella flipped by the strong wind. The transition state is not planar, but possesses rather twisted, S-shaped conformation Ci symmetry. bowl-inversion mechanism follows quadruple-w...

Bowl-in-bowl stacking of buckybowls on a copper surface is observed via scanning tunneling microscopy (STM) at low temperatures and characterized by density functional theory (DFT) calculations.

BACKGROUND Oral tacrolimus therapy is effective for refractory ulcerative colitis (UC), but dose adjustment according to the trough concentrations which varies largely among individuals, is required. This study aimed to identify factors to predict the tacrolimus dose required for achieving the target trough level for remission induction of UC. METHODS Forty-seven consecutive UC patients who w...

Functional large-conductance Ca(2+)- and voltage-activated K(+) (BK) channels can be assembled from four alpha subunits (Slo1) alone, or together with four auxiliary beta1 subunits to greatly increase the apparent Ca(2+) sensitivity of the channel. We examined the structural features involved in this modulation with two types of experiments. In the first, the tail domain of the alpha subunit, w...

The features we present of the augmented bowl have been designed to exploit our commonsense understandings and everyday uses of container-like objects. As we’ll explain, in choosing the features, we’ve attempted to build on the ways in which physical content can be casually added to or retrieved from a bowl with little to no thought. We’ve also tried to capture the way bowls loosely contain the...

A survey given to animal shelters across the US reported food bowl guarding as one of the most common reasons for euthanasia and only 34% attempted to modify this guarding behavior. This study identified 96 dogs that guarded their food bowl during an assessment, and then placed them into a home on a modification program. Food guarding behavior was identified as stiffening, gulping, growling, fr...