In a recent study dealing with a mouse model of Trypanosoma evansi-associated disease, a remarkable synchrony between the parasitaemia peak and the white-blood-cell count nadir was noticed. The present study was designed to establish whether there is a direct causal link between the parasite load during its exponential phase of growth and the disappearance of peripheral blood leukocytes. In vit...

Surra is an animal pathogenic protozoan infection, caused by Trypanosoma evansi, that develops into a fatal wasting disease. Control measures rely on diagnosis and treatment. However, with the continuous emergence of drug resistance, this tactic is failing, and the pressing need for new chemotherapeutic agents is becoming critical. With the introduction of novel aromatic diamidines, a new categ...

Wild animals are infected by diverse parasites, but how they influence host health is poorly understood. We examined the relationship of trypanosomatids and gastrointestinal parasites with health of wild brown-nosed coatis (Nasua nasua) from the Brazilian Pantanal. We used coati body condition and hematological parameters as response variables in linear models that were compared using an inform...

The use of plant-derived natural products for the treatment tropical parasitic diseases often has ethnopharmacological origins. As such, plants grown in temperate regions remain largely untested novel anti-parasitic activities. We describe here a screen PhytoQuest Phytopure library, source comprising over 600 purified compounds from zone plants, against vitro culture systems Plasmodium falcipar...

Accepted: 29/09/2015 Abstract Trypanosoma evansi and T. theileri are the two species of trypanosomes recorded from Karnataka state. The former one is the common species of livestock, dogs and zoo animals, but the latter was rarely reported from bovines. Only low infection rate of clinical cases of T. evansi in bovines was observed based on routine staining of blood smears. The efficacy of wet s...

The aim of this study was to test the susceptibility of mice to Trypanosoma evansi treated with human plasma containing different concentrations of apolipoprotein L-1 (APOL1). For this experiment, a strain of T. evansi and human plasma (plasmas 1, 2, and 3) from 3 adult males clinically healthy were used. In vivo test used 50 mice divided in 5 groups (A to E) with 10 animals in each group. Anim...

"Mal de Cadeiras", an enzootic disease caused by Trypanosoma evansi, is one of the most important trypanosomiases in the Brazilian Pantanal region. The disease affects mainly horses, which are widely used in extensive cattle production, an activity of greatest economical significance for the region. The parasite also infects sylvan (coatis and capybaras) and domestic (dogs) animals, respectivel...

BACKGROUND Trypanosoma (T.) evansi is a dyskinetoplastic variant of T. brucei that has gained the ability to be transmitted by all sorts of biting flies. T. evansi can be divided into type A, which is the most abundant and found in Africa, Asia and Latin America and type B, which has so far been isolated only from Kenyan dromedary camels. This study aimed at the isolation and the genetic and ph...

Trypanosomoses are protozoan diseases, affecting both human and animals, and mainly found in tropical Africa, Latin America and Asia. In Africa, trypanosomes produce serious diseases in human beings such as West and East Sleeping Sickness caused by T. brucei gambiense and T. brucei congolense respectively, while in the Americas T. cruzi causes the Chagas disease. Other species of Trypanosoma af...