lntraand interindividual components of biological variation have been determined for total thyroxin (TT4), free thyroxin (FT4), total triiodothyronine (TT3), free tniodothyronine (FT3), and thyrotropin (TSH). Calculated analytical goals (CV, %) for the precision required for optimal patient care are: TT4 2.5, FT4 4.7, TT3 5.2, FT3 3.9, and TSH 8.1. The marked degree of individuality demonstrate...

Most pregnant women are exposed to bisphenols, a group of chemicals that can interfere with various components the thyroid system. To investigate association maternal urinary bisphenol concentrations during pregnancy maternal, newborn and early childhood function. This study was embedded in Generation R, prospective, population-based birth cohort (Rotterdam, Netherlands). Maternal urine samples...

Concannon, Patrick W., V. Daniel Castracane, Richard E. Rawson, and Bud C. Tennant. Circannual changes in free thyroxine, prolactin, testes, and relative food intake in woodchucks, Marmota monax. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1401–R1409, 1999.— Woodchucks (n 5 12–14/group) with circannual cycles entrained to northern versus southern hemisphere photoperiods wer...

OBJECTIVE To examine the association between thyroid profile and morbidity/mortality (MM) in hospitalized older patients. DESIGN This is a retrospective study of patients over the age of 60 yr admitted to the Dr. Cesar Milstein Hospital between 2009 and 2010 and who had thyroid function tests (TFT). The patients were grouped as per their thyroid tests and their clinical characteristics and MM...

Antarctic residence (AR) is associated with a 50% increase in the thyrotropin (TSH) response to TSH-releasing hormone (TRH) and an expanded triiodothyronine (T3) distribution volume and extravascular hormone pool, collectively called the polar T3 syndrome. To investigate the possible biologic significance of this syndrome, we studied the relationship between nonstimulated TSH and serum lipid pr...

Chronic fatigue syndrome (CFS) is a heterogeneous disease with unknown cause(s). CFS symptoms resemble a hypothyroid state, possibly secondary to chronic (low-grade) (metabolic) inflammation. We studied 98 CFS patients (21-69 years, 21 males) and 99 age- and sex-matched controls (19-65 years, 23 males). We measured parameters of thyroid function, (metabolic) inflammation, gut wall integrity and...

Flavonols, phenylalanine-derived secondary metabolites, have protective and regulatory functions in plants. In Arabidopsis thaliana, they are consecutively glycosylated at their 3-OH and 7-OH groups. UGT78D1 and UGT78D2 are the major flavonol 3-O-glycosyltransferases in Arabidopsis leaves. The ugt78d1 ugt78d2 double mutant, which was strongly compromised in the initial 3-O-glycosylation, showed...

BACKGROUND Thyroid function changes during pregnancy, complicating the diagnosis of thyroid disorders. Maternal thyroid dysfunction has been associated with a variety of adverse outcomes. We evaluated thyroid function test results by ethnicity and week of gestation during the 2nd trimester of pregnancy. METHODS We collected 3064 blood specimens in serum tubes from Asians (13%), blacks (22%), ...

OBJECTIVE Certain epidemiological studies have suggested exposure to polybrominated diphenyl ethers (PBDEs) affect the production and secretion of thyroid hormones (TH); however, conflicting results have been reported in different studies. There is not a convincing conclusion about this debate to date. MATERIALS AND METHODS To perform a meta-analysis determining if there are correlations betw...