Benzimidazole is a bicyclic heterocyclic aromatic compound in which benzene fused to imidazole moiety. holds vital role the field of medicinal chemistry possesses wide variety pharmacological activities like antibacterial, anti cancer, antifungal, antileishmanial, tubercular, viral and malarial respectively, hence benzimidazole moiety attracting chemist synthesize different derivatives with act...

The current study reports design and diversity oriented synthesis of novel heterocycles incorporating of thioureido linkage on position no C-4 which not yet been explored and could find new applications in biology. Employing reagent based skeletal diversity approach; a facile synthesis of heterocycles with thioureido linkage at C-4 position of the quinazoline moiety has been accomplished. All t...

Scleritis is a severe painful inflammatory process centred in the sclera. A scleritis may be a harbinger of many systemic diseases so that it is important to exclude multisystem disease. We describe a case of unilateral tubercular anterior nodular non-necrotizing scleritis. Anterior nodular non-necrotizing scleritis is relatively an uncommon manifestation of tuberculosis. It may be difficult to...

A,ariery of infectious agents have been implicated the etiology of TA viz. streptococcus and ~Icobacteriumtuberculosis. Evidence of infection with ·uberculosis has been reported on the basis of presence ofco-existent tubercular lesion in lungs and para-arotic Ilmph nodes as well as report of presence of Langhans gl3nl cells in lesions olTA. It is important to note that in Japan where disease is...

BACKGROUND Lack of uniform diagnostic criteria often poses a challenge in the diagnosis and management of tubercular uveitis. The index case describes an unusual presentation of tubercular panuveitis initially misdiagnosed as sympathetic ophthalmia, where the appropriate diagnosis was made using various imaging and laboratory investigations. RESULTS A 52-year-old Indian woman underwent multim...

Recently, Lodhi SA and colleagues have reported on a patient with choroidal neovascular membrane (CNVM) associated with tubercular granuloma, who responded to intravitreal bevacizumab injections. The available literature regarding CNVM associated with intraocular tuberculosis is briefly discussed. Choroidal neovascular membrane is a possible complication of choroidal tuberculosis and the patien...

Multi-Detector Computed Tomography (MDCT) increases the accuracy of diagnosis for cases of acute appendicitis (1, 2). The imaging findings of acute appendicitis are well documented which include a dilated nonopacified appendix, fat stranding, and an appendicolith (1). Acute appendicitis arises from an appendicolith or obstruction of the appendix. The appendix is also involved in intestinal infl...

OBJECTIVE This study aims to evaluate the diagnostic efficacy of adenosine deaminase in tubercular effusions. METHODS This study was conducted at the Department of General Medicine and Cardiovascular and Thoracic Surgery, SKIMS, for a period of two years between November 2008 and November 2010. A total of 57 patients presenting with pleural effusions during the two-year study period, who pres...

Objectives: The present study was undertaken for investigating the protective effect of ethanolic extract of Mirabilis Jalapa Linn leaves on antitubercular drugs induced hepatotoxicity. Methods: Anti-tubercular drugs were used to induce hepatotoxicity in rats. Silymarin was used as standard drug (100 mg/kg p.o.). Ethanolic extract of leaves of Mirabilis Jalapa Linn (250 & 500 mg/kg p.o.) was ad...

We report a 38-year-old Chinese woman with lupus nephritis on peritoneal dialysis and long-term maintenance steroid therapy. This patient developed paradoxical deterioration during anti-tubercular therapy for tuberculous lymphadenitis. The deterioration resolved spontaneously without change to pharmacotherapy. Paradoxical deterioration that may spontaneously resolve is a potential complication ...