background: previous researches about the effects of epididymal obstruction on the testes are contradictory, and the mechanism harmful effect of male duct system obstruction on seminiferous tubules still remains unclear. objective: the aim of this study was to investigate the effects of epididymal obstruction in prepubertal rats on the testis. materials and methods: 15 days of age, the young ra...

In three separate sets of studies, the effects of ureteral ligation and coadministration of cadmium with cysteine or glutathione (GSH) (in either a 4:1 or 2:1 ratio of thiol to cadmium) on the renal disposition of cadmium were assessed in rats 1 h after the administration of cadmium. In all experiments, co-administration of cadmium with either cysteine or GSH caused the renal accumulation of ca...

The aim of the present study was to investigate the androgen receptor (AR) distribution in epididymal cells of developing rats and the effects of prepubertal epididymal obstruction upon AR distribution in the rat caput epididymis. At 15 days of age, the young rats were divided at random into groups for epididymal ligation or sham operation. In the ligation group the corpus epididymides were lig...

Oxidative stress has been implicated to play a major role in multiorgan dysfunction during sepsis. To study the mechanism of oxidant generation in acute kidney injury (AKI) during sepsis, we developed an in vitro model of sepsis using primary cultures of mouse cortical tubular epithelial cells exposed to serum (2.5-10%) collected from mice at 4 h after induction of sepsis by cecal ligation and ...

This study was designed to examine the effect of losartan treatment on renal tubular function in rats with mild congestive heart failure (CHF) induced by ligation of the left anterior descending artery. In rats with CHF, there was a significant decrease in daily sodium excretion, which caused sodium retention relative to control rats. Renal function studies revealed that glomerular filtration r...

BACKGROUND In addition to lowering blood glucose in patients with type 2 diabetes mellitus, dipeptidyl peptidase 4 (DPP4) inhibitors have been shown to be antifibrotic. We have previously shown that cation independent mannose-6-phosphate receptor (CIM6PR) facilitates the conversion of latent to active transforming growth factor β1 (GFß1) in renal proximal tubular cells (PTCs) and linagliptin (a...

One of the key mechanisms involved in renal Na(+) retention in chronic heart failure (CHF) is activation of epithelial Na(+) channels (ENaC) in collecting tubules. Proteolytic cleavage has an important role in activating ENaC. We hypothesized that enhanced levels of proteases in renal tubular fluid activate ENaC, resulting in renal Na(+) retention in rats with CHF. CHF was produced by left coro...

a case of renal tubular acidosis (rta) who had gradual onset of paralysis of lower extremities and persisted for a long time is presented. his primary workups were mistaken for muscular dystrophy. eventually, an abdominal ultrasonography revealed small stones in both of the kidneys and his workup for the stones were in favor of distal renal tubular acidosis and advanced rickets with hypokalemia...

A 7-year-old boy presented with recurrent cholangitis, failure to thrive, and progressive splenomegaly. On examination, he had severe pallor, clubbing, and splenohepatomegaly. Lab results showed anemia (hemoglobin 7.2 g/dL) and normal liver functions. Abdominal ultrasound showed hepatosplenomegaly with coarsened liver echotexture and multifocal intrahepatic biliary radical (IHBR) dilatation. Th...

OBJECTIVE To assess the outcome of arterial duct occlusion with coils chosen according to the duct morphology. DESIGN Retrospective study. SETTING Paediatric cardiology centre. PATIENTS Coil occlusion was attempted in 57 patients aged 0.5 to 15 (median 3.7) years and weighing 5-59 (median 14) kg between January 1991 and December 1995. A residual leak was present in 8 patients after umbrel...