Tumefactive multiple sclerosis comprises a rare subset of that often poses diagnostic challenge to physicians. It is unique in its presentation as solitary lesion, usually larger than 2 cm, with surrounding vasogenic edema, commonly mimicking primary intracranial malignancy. We present case 25-year-old female no significant past medical history who presented our institution homonymous superior ...

Fingolimod (FTY) is the first oral medication approved for treatment of relapsing-remitting multiple sclerosis (RRMS). Its effectiveness and safety were confirmed in several phase III clinical trials, but proper evaluation of safety in the real patient population requires long-term post-marketing monitoring. Since the approval of FTY for RRMS in Japan in 2011, it has been administered to approx...

AIM In demyelinating disease spectrum, tumor-like (tumefactive) demyelinating lesions (TDL) are rarely seen. Atypical imaging and clinical features of these lesions may cause misdiagnosis of tumor or abscess. MATERIAL AND METHODS 25 patients with TDL in our center were followed and clinical, magnetic resonance imaging (MRI), magnetic resonance spectroscopy, cerebrospinal fluid (CSF) findings ...

Finglimod, a sphingosine 1-phosphate receptor modulator, is the first orally administered therapy approved for prophylaxis in multiple sclerosis (MS). Several reports in the last two years suggested that it might be associated with severe augmentation of disease activity upon initiation or discontinuation of therapy. We present an MS patient who developed a giant cavitating brain lesion under f...

A 25-year-old man suffered from recurrent, mass-like, intracerebral lesions and was diagnosed with tumefactive multiple sclerosis (MS). Both interferon β-1b and oral methotrexate (7.5 mg weekly) could not suppress frequent relapses, but he had been in remission for 8 months by the mitoxantrone treatment. At the age of 27, the patient developed a partial seizure. Brain MRI revealed a lesion in t...

BACKGROUND Tumefactive demyelinating lesions (TDLs) are associated with a variety of demyelinating diseases in the central nervous system (CNS). However, there are no current guidelines describing how to classify and treat patients with this rare phenotype. Thus, the present study aimed to determine the long-term evolution and disease course of patients initially presenting with TDLs and to des...

BACKGROUND AND PURPOSE The brain perivascular spaces (PVSs) are pial-lined, interstitial fluid-filled structures that accompany penetrating arteries. When enlarged, they may cause mass effect and can be mistaken for more ominous pathologic processes. The purpose of this study was to delineate the broad clinical and imaging spectrum of this unusual condition. METHODS Thirty-seven cases of gian...

Purpose: To present a clinical case of tumefactive multiple sclerosis (TMS), which is an inflammatory demyelinating disease the central nervous system considered to be rare form (MS). It belongs group borderline forms MS – collective term used define spectrum demyelination-associated neurological conditions that share similar clinical, neuroimaging and histopathological features but vary widely...