Malignant cells thrive in a highly specialized, stromal environment, which harbors support cells, blood vessels, and diverse leukocyte populations. There is increasing evidence that "by default", intratumoral inflammation fosters angiogenic and vasculogenic processes and simultaneously creates an immunosuppressive micromilieu. This self-amplifying loop of proangiogenic inflammation represents a...

Administration of 9a-fluoroprednisolone to mice bearing the corticoid-sensitive strain of Lymphosarcoma PI 798 resulted in a prompt regression of tumor size. This regression was accompanied by a selective decrease in tumor RNA. Tumor DNA con centration remained at control levels. These changes were preceded by an increased tumor ribonuclease activity in homogenates of tumor after the in vivoadm...

A 7½-year-old girl is reported showing pre­cocious puberty and large abdominal mass for a year. The right ovarial cyst removed by surgery revealed histopathologically a granu­losa cell tumor. After removal of the tumor the estrogens were still increased and the signs of puberty showed no regression. This seems to be due to the hormonal activity of the metas­tases. Liver metastasis was present a...

BACKGROUND High interobserver variation is a well known drawback of conventional tumor regression grading, and reaching consensus among pathologists may require a considerable effort. Therefore, in this study, morphometry was tried to assess tumor regression, and its prognostic role was explored. METHODS Tumor regression was quantified by a point counting method to yield tumor area fraction (...

Introduction: Glioblastoma multiforme (GBM) is an aggressive case of primary brain cancer which remains among the most fatal tumors worldwide. Although, some in vitro and in vivo models have been developed for a better understanding of GBM behavior; a natural model of GBM would improve the efficiency of experimental models to human GBM tumors. We aimed at the present study to examine the surviv...

OBJECTIVES We describe patterns of tumor regression based on follow-up duration after radiotherapy (RT) or chemo-RT in patients with head and neck squamous cell carcinoma. METHODS Thirty-one patients with head and neck squamous cell carcinoma were included in this study and received definitive RT or chemo-RT. The pattern of primary tumor regression after treatment was evaluated every 1 to 2 m...