Of the many health benefits attributed to selenium, the one that has received the most attention is its role in cancer prevention. Selenium-containing proteins (selenoproteins) have been shown in recent years to have roles in cancer prevention. However, selenoproteins have diverse functions and their view as antioxidants is oversimplified. Some selenoproteins appear to have a split personality ...

Thiophosphate (SPO(3)) was recently shown to promote cysteine insertion at Sec (selenocysteine)-encoding UGA codons during selenoprotein synthesis. We reported previously that irreversible targeting by cDDP [cis-diamminedichloroplatinum(II) or cisplatin] of the Sec residue in TrxR1 (thioredoxin reductase 1) contributes to cDDP cytotoxicity. This effect could possibly be attenuated in cells expr...

Exposure to ultraviolet radiation (UVR) and airborne pollution, particularly in the form of particulate matter sized 2.5 μm (PM2.5), is associated with signs skin aging inflammation. Damage from UVR PM2.5 believed be result oxidative stress, therefore, we examined effects a novel composition containing three antioxidants an vitro model system order better understand their potential. We focused ...

BACKGROUND Endothelial dysfunction precedes pathogenesis of vascular complications in diabetes. In recent years, the mechanisms of endothelial dysfunction were investigated to outline strategies for its treatment. However, the therapies for dysfunctional endothelium resulted in multiple clinical trial failures and remain elusive. There is a need for defining hyperglycemia-induced endothelial dy...

Recently, much attention is paid to the phenomenon of gene’s hypermethylation in the peripheral blood (PB) and its involvement in the pathology of cancer. Breast cancer is a complex disease driven by multiple factors including both genetic and epigenetic processes. Genetic changes associated with breast cancer are not completely known, but epigenetic mechanisms involved in this disease seem to ...

Introduction: Polymorphisms are the main genetic factors associated with toxicities of antituberculosis drugs. This literature review summarizes polymorphisms genes that code for enzymes metabolism drugs and their transmembrane transporters. Some mechanisms drug-associated strategies management have also been described in this review. Methods: The bibliographic searches were exclusively carried...

In this review, we describe a rat model for chemically induced hepatocarcinogenesis that can be used for studying the anticarcinogenic effects of different agents. In this model the process of carcinogenesis can be followed through the different stages of initiation, promotion and progression. Mechanistic studies of anticarcinogenic agents can be carried out and two examples are given by studie...