patients with type 1 diabetes mellitus have a high prevalence of coeliac disease, symptoms of which are often mild, atypical, or absent. untreated coeliac disease is associated with an increased risk of malignancy, particularly of lymphoma. therefore, we report a 9-year-old girl with coeliac disease, diabetes type 1 and selective iga deficiency. a 9-year-old female patient presented in august 2...

background: type 1 diabetes (t1d) is caused by cell-mediated autoimmune attack on pancreatic beta-cells. previous studies highlight the role of micrornas (mirnas) in the pathogenesis of t1d. mirnas are small non-coding rnas involved in the regulation of gene expression post-transcriptionally. in this work, mir-18b was chosen and the differential expression of it was measured between t1d patient...

the biobreeding- diabetes prone (bb-dp) rat spontaneously develops an autoimmune diabetic syndrome that is dependent on the rt1 u major histocompatibility complex (mhc) haplotype and homozygosity for an allele at the lymphopenia (lyp) locus. lyp mutation is responsible for a peripheral t -lymphopenia. there are other genetic loci contributing to diabetes susceptibility in this strain. bb rats c...

conclusions finally, based on the results obtained in this study, it can be concluded that the awareness of mothers of t1dm children has a good impact on blood sugar control, whereas the ses of families has no direct effect on blood sugar control. additionally, ses can indirectly impact on the consciousness of mothers and lead to the reduction of hba1c. results mothers’ mean knowledge score was...

Background & Aims: Changing the hormonal output of endocrine glands, diabetes leads to the occurrence of secondary metabolic disorders. Neuropathy, on the other hand, is the most common neurological complication of diabetes which affects the neuroendocrine system, in addition to peripheral and autonomic nervous system, contributing to exacerbation of disease severity. In this line, the present ...

The herpesviruses infections in equides are caused by five different serotypes of viruses, belonging to family Herpesviridae. The goal of this study was to conduct a seroepidemiological investigation of equine herpesvirus type 1 (EHV-1) and type 4 (EHV-4) in horses and donkeys raised in two provinces and their villages in northeastern Turkey. A total of 666 samples from 423 horses and 243 donke...

human t-cell lymphotropic virus type-i (htlv-i) was the first human retrovirus associated with malignancy.  the prevalence of htlv-i infection varies significantly in different regions of the world.  in this study, the prevalence of htlv-i infection among ethnic jews living in shiraz, south of iran, was investigated. 286 blood samples were obtained.  htlv-1 antibody assay on serum samples was d...

the hallmarks of leukocyte adhesion deficiency (lad) are defects in the leukocyte adhesion process, marked leukocytosis and recurrent infections. these molecular and clinical manifestations result from an impaired step in the inflammatory process, namely, the emigration of leukocytes from the blood vessels to sites of infection, which requires adhesion of leukocytes to the endothelium. over las...