For most patients with type I diabetes, insulin therapy and glucose monitoring are sufficient to maintain glycemic control. However, hypoglycemia is a potentially lethal side effect of insulin treatment in patients who are glycemically labile or have hypoglycemia-associated autonomic failure [1]. For those patients, an alternative therapy is beta cell replacement via pancreas or islet transplan...

Tubular function was investigated in patients with diabetic ketoacidosis and those with poorly controlled type I diabetes. Urinary excretion of beta 2 microglobulin and that of certain enzymes: gamma glutamyltransferase, leucine aminopeptidase, and N-acetyl-beta-D-glucosaminidase activities were significantly raised during ketoacidosis in 11 patients compared with healthy controls. In 13 poorly...

Type I and type II diabetes mellitus, characterized by increased blood glucose levels, affect almost half a billion people around the world [...]

type 1 diabetes mellitus is frequently associated with autoimmune thyroid disease (atd).genetic susceptibility for autoantibody formation in association with atd and type 1 diabetes mellitus has been described with varying frequencies, but there is still debate about its prevailing situation in iran.  we have therefore investigated the prevalence of anti-thyroid peroxidase (anti-tpo) and anti t...

Patients with diabetes are subdivided into at least two subgroups: those with insulindependent diabetes mellitus (Type I) and those with non-insulin-dependent diabetes mellitus (Type II). Both groups of patients have abnormalities in the sensitivity of their tissue to insulin, as well as abnormalities in beta (B)-cell function. In type I diabetes, a marked decrease in the number of B-cells is t...

objective: to identify the proportion and some selected characteristics of juvenile diabetics attending birdem hospital. materials and methods: this was a cross sectional study. the study was conducted in the birdem hospital. all diabetic young aged up to 18 years who visit birdem hospital were included in study population. the sample size was 240. results: it was observed that among the respon...

Background: Pancreatic islet transplantation is one of the most promising strategies for treating patients with type I diabetes mellitus.Objective: We aimed to assess the immunoisolation properties of the multilayer encapsulated islets using alginate-chitosan-PEG for immunoprotection and insulin secretion from the encapsulated islets induced under differe...