Plasma cell antigen (PC-1) is an inhibitor of insulin receptor tyrosine kinase, which plays an important role in insulin resistance pathogenesis in type 2 diabetes mellitus, obesity and some other insulin resistant states. In a recent study we have demonstrated an increased lymphocyte PC-1 activity in patients with type 2 diabetes and its reversal by 3-month metformin treatment, corresponding t...

conclusions regarding the results, it could be suggested that the reason for not being able to control diabetes was the existence of differences among viewpoints while by getting to know the obstacles for controlling diabetes from the viewpoints of the three studied groups, more effective planning for controlling diabetes could be possible. results the results of this research showed that there...

Background: To evaluate the efficacy of adding the glutazone to maximum dose of sulfonylurea and metformin in patients with poorly controlled type 2 diabetes. Methods: Ninety six patients with type 2 diabetes who had failed medical therapy with maximal-dosage of metformin and glibenclamide received glutazone. Fasting blood sugar (FBS), 2 hours postprandial (2hpp) glucose, hemoglobin A1C, chol...

Type 2 diabetes mellitus is a major risk factor for melioidosis, which is caused by Burkholderia pseudomallei. Our previous study has shown that polymorphonuclear neutrophils (PMNs) from diabetic subjects exhibited decreased functions in response to B. pseudomallei. Here we investigated the mechanisms regulating cytokine secretion of PMNs from diabetic patients which might contribute to patient...

Gliclazide has been reported to decrease platelet function and to inhibit the progression of diabetic retinopathy in addition to having a hypoglycemic effect. To confirm these effects we performed a double-blind randomized study using glibenclamide as a reference drug. Thirty-eight hospitals from eight university groups in Japan performed the study on type II diabetic subjects. Evaluation of bl...

Introduction: Diabetes mellitus (DM) is a multi-factorial condition associated with oxidative stress. Limonene, as plant-derived antioxidant, can be used for treating DM. Objectives: An investigation on antioxidant effects in diabetic rats exposed to D-limonene. Materials and Methods: Sixty male Wistar were categorized into six groups follows: control (healthy rats), (untreated sham glibenclami...

Loss of -cell mass and function raises a concern regarding the application of sulfonylureas for the treatment of type 2 diabetes because previous studies have shown that agents that cause closure of inwardly rectifying K sulfonylurea receptor subtype of ATP-sensitive potassium channels, such as tolbutamide and glibenclamide, induce apoptosis in -cell lines and rodent islets. Therefore, we inves...