This review presents a critical evaluation of the role of Helicobacter pylori eradication in the management of peptic ulcer disease and non-ulcer dyspepsia. On current evidence, H. pylori eradication therapy seems likely to emerge as the most rational and cost-effective treatment for duodenal ulcer. The role of H. pylori eradication in the treatment of gastric ulcer and non-ulcer dyspepsia is u...

AIMS To determine the association, if any, between H pylori genotype and the gastric mucosal variations in the levels of gastrin, somatostatin, tryptase, and histamine. METHODS 49 patients affected by duodenal ulcer and 48 by non-ulcer dyspepsia were studied. To identify the H pylori genotype, the presence of the cagA gene and vacA alleles m1, m2, s1, and s2 were analysed by polymerase chain ...

AIMS To determine the relation among the cytotoxin associated gene (cagA) and vacuolating cytotoxin gene (vacA) status of Helicobacter pylori isolates, the associated clinical diseases, and the severity and pattern of chronic gastritis. METHODS Helicobacter pylori was cultured from gastric biopsies obtained from dyspeptic patients. DNA was extracted from the isolates and the cagA and vacA sta...

introduction: dyspepsia, gastroesophageal reflux disease (gerd) and irritable bowel syndrome (ibs) are the most common gastrointestinal diseases. their prevalence is 18-30%, 25-30% and 10-15% in western communities and 8-14%, 3-7% and 3-5% in eastern countries, respectively. there is no adequate data about their prevalence in our country. the aim of this study is to determine the prevalence of ...

BACKGROUND/AIMS It remains controversial whether Helicobacter pylori infection causes symptoms in non-ulcer dyspepsia. One hundred non-ulcer dyspepsia patients were screened for H. pylori infection between November 1989 and February 1994. Forty patients entered a trial where both infected and uninfected patients were treated with H. pylori therapy, with the uninfected group serving as controls....

seen in the primary care setting. We believe, however, that our findings would need to be assessed in the primary care setting before implementation is considered. Contributors: See bmj.com Funding: No pharmaceutical company or other commercial entity provided funding or other resources for the study. Competing interests: None declared. Ethical approval: The local ethics committee approved the ...

abstract background: the role of psychological factors in peptic ulcer disease (pud) and functional dyspepsia (fd) has not been clearly determined. in this study the role of conflict management styles, psychiatric symptoms, and alexithymia were assessed in patients with pud and fd and in the healthy individuals. methods: ninety subjects [30pud (15 women, 15 men), 30 fd (15 women, 15 men), and 3...

background: cd1d presents glycolipid antigens to invariant natural killer t (inkt) cells. the role of cd1d in the development of peptic ulcer and gastric cancer has not been revealed, yet. objective: to clarify the expression of alternatively spliced variants of cd1d in peptic ulcer and gastric cancer. methods: patients with dyspepsia were selected and divided into three groups of non-ulcer dys...