In populations with a high (≥14) median National Institute of Health Stroke Score (NIHSS), a normal finding of Thrombolysis in Brain Ischemia grade 5 (TIBI 5) in the artery of interest has been reported to be an unusual finding when transcranial ultrasound is performed during thrombolysis. In such instances, a stroke mimic can be suspected, but there are alternative pathophysiological explanati...

BACKGROUND Numerous acute reperfusion therapies (RPT) are currently investigated as potential new therapeutic targets in acute ischemic stroke (AIS). We conducted a comprehensive benefit-risk analysis of available clinical studies assessing different acute RPT, and investigated the utility of each intervention in comparison to standard intravenous thrombolysis (IVT) and in relation to the onset...

R ecent developments in thrombolysis therapy using tissue Plasminogen Activator (tPA) in combination with ultrasound for noninvasive stroke treatment are of great excitement. The first clinical trials have been successfully initiated, demonstrating the potential benefit of transcranial ultrasound in combination with tPA as an effective vessel recanalizing treatment strategy. 6–10 The use of tPA...

775 Reperfusion after stroke sonothrombolysis with microbubbles may predict intracranial bleeding L. Dinia, M. Rubiera, M. Ribo, O. Maisterra, G. Ortega, M. del Sette, J. Alvarez-Sabin, and C.A. Molina 781 Neurologic abnormalities in HTLV-I– and HTLV-II–infected individuals without overt myelopathy H.H. Biswas, J.W. Engstrom, Z. Kaidarova, G. Garratty, J.W. Gibble, B.H. Newman, J.W. Smith, A. Z...

Background and Purpose—Sonothrombolysis is a new treatment approach in acute ischemic stroke. The results of a monocenter, randomized clinical study are presented. Methods—Subjects with acute middle cerebral artery main stem occlusion were randomized into a target group receiving 1-hour transcranial continuous insonation using a 1.8-MHz Doppler ultrasound (US) probe or a control group. All unde...