Recent technological improvements in the elastic substrate method make it possible to produce spatially resolved measurements of the tractions exerted by single motile cells. In this study we have applied these developments to produce maps of the tractions exerted by 3T3 fibroblasts during steady locomotion. The resulting images have a spatial resolution of 5 m and a maximum intensity of 10 kdy...

...................................................................................................................4 Chapter 1: Introduction..........................................................................................5 1.1 Mechanics in Cancer Metastasis....................................................................................5 1.2 Previous Works..............................

A new meshless Local Boundary Integral Equation (LBIE) method for solving two-dimensional elastostatic problems is proposed. Randomly distributed points without any connectivity requirement cover the analyzed domain and Local Radial Basis Functions (LRBFs) are employed for the meshless interpolation of displacements. For each point a circular support domain is centered and a local integral repr...

A fluid droplet, in general, deforms if subject to active driving, such as a finite slip velocity or tractions on its interface. Starting from Stokes equations, we show that these deformations and their dynamics can be computed analytically perturbation theory the inverse of surface tension γ, by using an approach based vector spherical harmonics. We consider squirmer models general tractions, ...

Non-uniform rational B-splines (NURBS) are a convenient way to integrate CAD software and analysis codes, saving time from the operator allowing efficient solution schemes that can be employed in of complex mechanical problems. In this paper, Isogeometric Boundary Element Method coupled with Bézier extraction NURBS conventional BEM used for 2D contact problems under cyclic loads. A node-pair ap...

A hybrid space and spatial transform convolution method is developed for computing source time functions based on numerically solving an integral equation formulation of the mixed boundary value problem for fault displacements and tractions. The space domain method is an adaptation of the method of Das (1980) in which the displacements on the broken region of the crack and the tractions on the ...

Abstract We use three-dimensional (3-D) dynamic finite-element models to investigate potential rupture paths of earthquakes propagating along faults through the western San Gorgonio Pass, a structurally complex region Andreas fault system in southern California (USA). focus on right-lateral Bernardino strand system, oblique thrust–right-lateral Pass zone, and portion Garnet Hill system. 3-D met...