This special issue is devoted to new developments in measurement technologies for upstream and downstream bioprocessing [...]

Carrier proteins, 80-100 residues in length, serve as information-rich platforms to present growing acyl and peptidyl chains as covalently tethered phosphopantetheinyl-thioester intermediates during the biosynthesis of fatty acid, polyketide, and nonribosomal natural products. Carrier proteins are recognized both in cis and in trans by partner catalytic domains that effect chain-elongating cond...

Wemodel a credit network characterized by credit relationships connecting (i) downstream (D) and upstream (U) firms and (ii) firms and banks. The net worth of D firms is the driver of fluctuations. The production of D firms and of their suppliers (U firms) in fact, is constrained by the availability of internal finance—proxied by net worth—to the D firms. The structure of credit interlinkages c...

An experiment featuring waterhammer in viscoelastic pipes is presented in which the effects of pipe-wall viscoelasticity on waterhammer pressures are investigated. A large-scale pipeline apparatus made of polyvinyl chloride (PVC) at Deltares, Delft, The Netherlands, has been used to carry out waterhammer experiments. Tests have been conducted in a reservoir-pipeline-valve system consisting of a...

More than 5% of alternatively spliced internal exons in the human genome are derived from Alu elements in a process termed exonization. Alus are comprised of two homologous arms separated by an internal polypyrimidine tract (PPT). In most exonizations, splice sites are selected from within the same arm. We hypothesized that the internal PPT may prevent selection of a splice site further downstr...