نتایج جستجو برای: urate deposition
تعداد نتایج: 96523 فیلتر نتایج به سال:
Gout is a debilitating disease secondary to chronic hyperuricemia, and the subsequent deposition of monosodium urate crystals is responsible for acute flare, gout arthropathies, tophi and renal lithiasis. Uric acid is the end product of purine metabolism in humans because the gene encoding uricase was lost during hominoid evolution. Pegloticase is a recombinant mammalian uricase conjugated to p...
Membrane transport pathways mediating transcellular secretion of urate across the proximal tubule were investigated in brush-border membrane vesicles (BBMV) isolated from avian kidney. An inside-positive K diffusion potential induced a conductive uptake of urate to levels exceeding equilibrium. Protonophore-induced dissipation of membrane potential significantly reduced voltage-driven urate upt...
ABCG2, also known as BCRP, is a high-capacity urate exporter, the dysfunction of which raises gout/hyperuricemia risk. Generally, hyperuricemia has been classified into urate 'overproduction type' and/or 'underexcretion type' based solely on renal urate excretion, without considering an extra-renal pathway. Here we show that decreased extra-renal urate excretion caused by ABCG2 dysfunction is a...
Gout is the most prevalent inflammatory arthropathy. It displays a striking predilection to affect the first metatarsophalangeal joint (1 MTPJ) as well as joints within the mid-foot and ankle. The propensity of gout for the foot was recognised by the ancient Greeks who named it podagra, literally “foot-grabber”. A number of mechanisms have been proposed to explain this clinical observation. Hyp...
Grassl, Steven M. Urate/ -ketoglutarate exchange in avian basolateral membrane vesicles. Am J Physiol Cell Physiol 283: C1144–C1154, 2002. First published June 13, 2002; 10.1152/ajpcell.00379.2001.—Membrane transport pathways for transcellular secretion of urate across the proximal tubule were investigated in avian kidney. The presence of coupled urate/ -ketoglutarate exchange was investigated ...
Allopurinol is a xanthine oxidase inhibitor mainly used to reduce circulating urate (also known as uric acid) levels. This helps to prevent recurrent urate crystal deposition in the form of gout.1 Gout is relatively common in patients with renal failure. Although routine dose reduction of allopurinol is recommended in the hemodialysis (HD) population this is not based on evidence from robust cl...
Urate, the final oxidation product of purine metabolism, is excreted into urine in humans. Clinically, increased serum urate levels are indicative of pregnancy-induced hypertension (PIH). However, how urate is handled in the placenta is still largely unknown. In this study, we compared maternal serum urate levels with those of umbilical cord blood and investigated urate transport mechanisms in ...
Urate uroliths belong to the purine family of uroliths and are the third most common urolith type in dogs and cats. In dalmatians, an autosomal recessive trait is responsible for hyperuricosuria and a predisposition to urate urolithiasis. In other dog breeds and in cats, urate uroliths are predominantly associated with liver disease, specifically portosystemic vascular anomalies. Idiopathic ura...
Gout is a disorder of purine metabolism characterised by hyperuricemia, deposition of monosodium urate monohydrate crystals in joints and periarticular tissues with recurrent attack of acute synovitis. Rheumatoid arthritis (RA) and gout are relatively common disease, but their coexistence is extremely rare. We report a case of 69yrs old female on presentation likely to have rheumatoid arthritis...
Gout is a metabolic disease, which is characterized by acute or chronic arthritis, and deposition of monosodium urate crystals in joint, bones, soft tissues, and kidneys. But large tophi are unusual in chronic gout. We report the case of a 67-year-oldArabman presenting chronic tophaceous gout with unusual large tophi involving multiple joints: hands, feet, elbows, and knees. Laboratory workup r...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید