According to classical concepts, uric acid is presumably filtered at the renal glomeruli andl reabsorbed but not secreted by the renal tubules in man (Berliner et at., 1950). Recent work (Y#{252} and Gutman, 1959) suggests that uric acid may, however, be both secreted and reabsorbed by the tubules. In this species probenecid and salicylates may either increase renal excretion of uric acid, and ...

A practical procedure for evaluating uricosuric agents was demonstrated using clearance experiments with potassium oxonate-treated rats. The fractional excretion value of uric acid showed a reabsorptive net flux of uric acid in the renal tubules of the animal, though the value was obviously higher than those of primates such as men, chimpanzees and cebus monkeys. However, the rats responded wel...

Uric acid was used as a test for liver disease before the advent of enzymology. Three old studies criticised uric acid as a test of liver function. Uric acid, as an end-product of purine metabolism in the liver, deserved re-evaluation as a liver function test. Serum totalbile acids are widely accepted as the most reliable liver function test. This study compared the ability of serum uric acid c...

Maternal, fetal and neonatal complications are correlated with hypertensive disorders during pregnancy.  In this context, the maternal blood uric acid level is reported to be one of the prognostic factors in determining the prenatal outcome.  Based on the existing data, the present descriptive study was performed on two groups of women with severe preeclampsia; the first group (n=53) with a uri...

background: we aimed to estimate the glomerular filtration rate (gfr) in women with polycystic ovary syndrome (pcos) and to determine the relationship between gfr with c-reactive protein (crp) and uric acid. materials and methods: in this cross-sectional study, one-hundred and forty pcos women and 60 healthy subjects were evaluated. the study was carried out at endocrinology outpatient clinic, ...

High blood uric acid level is a risk factor for gout. To reduce the gout complications, patients need to measure their blood uric acid levels and take medication if necessary. Several commercial blood uric acid meters are available in the market. The aim of this study is to investigate the accuracy of two commercial blood uric acid meters, MultiSure and BeneCheck Pluse Meter, on blood uric acid...

Determination of the relative contribution of uric acid level increases to the total measured antioxidative activity could be very useful for testing antioxidative products and their effect on human health. The aim of this report is to present a simple spectrophotometric method that combines the measurement of total antioxidative capacity of a sample by ferric reducing/antioxidative power (FRAP...

OBJECTIVES Elevated levels of uric acid are often associated with cardiometabolic risk factors. The aim of this study was to determine whether uric acid levels differ between African and Caucasian women and whether uric acid is associated with cardiometabolic risk factors within the two ethnic groups. METHODS Women from African (N=102) and Caucasian (N=115) descent were recruited and their ur...

OBJECTIVES: To study the relationship between serum uric acid level and Killip classification in pateints with acute myocardial infarction (MI), and the use of serum uric acid levels as a marker of short-term mortality. METHODS: The present study involved 50 patients with acute MI and 50 controls. Serum uric acid level was measured on days 0, 3 and 7 of MI, and compared with all clinical parame...

Elevated serum uric acid level has been associated with increased cardiovascular risk in hypertensive patients. Several angiotensin II receptor blockers exhibit differential effects on regulation of serum uric acid level in humans. We have demonstrated that some angiotensin II receptor blockers trans-stimulate the uptake of uric acid by human URAT1 and others inhibit the transport of uric acid ...