Hyaluronic acid (HA), a glycosaminoglycan, is known to promote tumor cell adhesion and migration, and its small fragments stimulate angiogenesis. We compared levels of HA in the urine of normal individuals and patients with bladder cancer or other genitourinary conditions, using a sensitive ELISA-like assay. Among the 144 specimens analyzed, the urinary HA levels of bladder cancer patients with...

Regeneration of the urinary bladder is a complicated task, due to organ dimensions and diseases (cancer, interstitial cystitis) when autologous bladder cells cannot be used. Cancer is the most frequent indication for bladder removal (cystectomy). Stem cells can be used with the guarantee of the sufficient cell number for the in vitro construction of the urinary bladder wall. Tissue engineering ...

BACKGROUND Prostate cancer (PCa) originating from the prostate base may intrude into the urinary bladder and may be misdiagnosed as bladder cancer. In this retrospective study, we reviewed the clinic data on PCa cases which were initially misdiagnosed as bladder cancer in order to identify diagnostic methods that would allow a better differential diagnosis for PCa. METHODS Out of a total of 4...

Primary tumors of the appendix are rare, while malignant villous adenoma of the appendix invading the urinary bladder is extremely uncommon. We reported the present case of a 63-year-old male with malignant villous adenoma of the appendix invading the urinary bladder. The conventional cystoscope demonstrated a mass at the front right side wall of the urinary bladder, which misdiagnosed as bladd...

Urinary bladder cancers can be grouped into three general categories: superficial, invasive and metastatic. Approximately 90% of malignant tumors of the urinary bladder are of epithelial origin and the majority of them are transitional cell carcinomas (TCC). Metastatic spread of urinary bladder cancers usually includes regional lymph nodes, the lung, the liver and the bones. The presence of met...

PURPOSE HER-2/neu overexpression is documented in some bladder cancers. To our knowledge, there are no current studies evaluating urine HER-2/neu levels. Therefore, we examined the clinical significance of serum and urine HER-2/neu protein in bladder cancer. MATERIALS AND METHODS Urothelial bladder carcinoma patients (n=38, including 31 men and 7 women) and healthy controls (n=25, including 2...

Accurate and sensitive detection of bladder cancer is critical to diagnose this deadly disease at an early stage, estimate prognosis, predict response to treatment, and monitor recurrence. In past years, laboratory diagnosis and surveillance of urinary bladder cancer have improved significantly. Although urine cytology remains the gold standard test, many new urinary biomarkers have been identi...

Description of Procedure or Service Populations Interventions Comparators Outcomes Individuals:  With signs and symptoms of bladder cancer or a history of bladder cancer Interventions of interest are:  Urinary tumor marker tests Comparators of interest are:  Cytology  Cystoscopy  Biopsy Relevant outcomes include:  Overall survival  Disease-specific survival  Test accuracy  Test validit...

Bladder cancer is one of most common malignant urinary tract tumor types, and transurethral resection nonmuscle invasive bladder followed by intravesical instillation immunochemotherapy the standard treatment approach to minimize recurrence delay progression cancer. In general, conventional lacks selectivity for tissues effect drug reduced with excretion urine leading frequent administration ir...