Precision Drug Delivery In article number 2206989, Yu Tao, Mingqiang Li, Xuesi Chen, and co-workers report a membrane-fusogenic liposome to precisely convey two glycan-engineering drugs onto the cell membrane into cytoplasm for physical modification of natural-killer-cell-activating glycans biological inhibition immunosuppressing glycans, respectively, thus sufficiently arousing natural killer ...

to clarify the effect of γδ t cells and invariant natural killer t (inkt) cells in pathophysiology of dyspeptic disorders, number of these two cells in patients with non-ulcer dyspepsia (nud), peptic ulcer disease (pud), and gastric cancer (gc) were compared.patients with dyspepsia were divided into three groups of nud, pud, and gc according to their endoscopic and histopathological examination...

Natural killer (NK) cells are part of the innate immune defense against infection and cancer and are especially useful in combating certain viral pathogens. The utility of NK cells in human health has been underscored by a growing number of persons who are deficient in NK cells and/or their functions. This can be in the context of a broader genetically defined congenital immunodeficiency, of wh...

the  non-classical mhc  class-i mainly involves in the  regulation of  innate  immune responses where hla-e  plays a significant role in the cell identification by natural killer cells. hla-e is a main regulatory ligand for natural killer cells and given the importance of these effector cells in hematopoietic stem cell transplantation, we investigated the effect of hla-e polymorphisms on post-h...