the objective of the present study was to evaluate the pharmacokinetic parameters and bioavailability of a selective histamine (h1)-receptor antagonist, cetirizine hydrochloride (ctz), following administration of a single oral dose of the drug. the properties of a test compound were compared with those of a reference product in a randomized cross-over study in 12 volunteers. blood samples were ...

We investigated the hemodynamic determinants of the age-associated decline in maximal oxygen uptake (V(O2 max)) and the influence of gender on the decline in V(O2 max) and its determinants in old and very old men and women. Sedentary, 60- to 92-yr-old women (n = 71) and men (n = 29), with no evidence of cardiovascular disease, underwent maximal treadmill exercise tests during which V(O2 max) an...

Patients with obstructive and restrictive ventilatory abnormalities suffer from exercise intolerance and dyspnea. Breathing pattern components (volume, flow, and timing) during incremental exercise may provide further insight in the role played by dynamic hyperinflation in the genesis of dyspnea. This study analyzed the breathing patterns of patients with obstructive and restrictive ventilatory...

In this paper, we investigate the approximability of two node deletion problems. Given a vertex weighted graph G = (V,E) and a specified, or “distinguished” vertex p ∈ V , MDD(min) is the problem of finding a minimum weight vertex set S ⊆ V \ {p} such that p becomes the minimum degree vertex in G[V \ S]; and MDD(max) is the problem of finding a minimum weight vertex set S ⊆ V \{p} such that p b...

Myrosinase (thioglucoside glucohydrolase; EC 3.2.3.1) is a plant enzyme that hydrolyses glucosinolates, principally to isothiocyanates. Myrosinase was purified to homogeneity in good yield from 8-day-old seedlings of Raphanus sativus (daikon) using a four-step procedure involving chromatographies on anion exchange, hydrophobic Phenyl-Sepharose, gel filtration and concanavalin A-Sepharose. In or...

Zusammenfassung Unzweifelhaft haben Max Frisch und Friedrich Dürrenmatt der Literatur Schweiz nach 1945 zu internationalem Ansehen verholfen. Ihre besondere Stellung innerhalb verdankt sich nicht zuletzt ihrer kritischen Haltung gegenüber in weithin anerkannten politischen gesellschaftlichen Gepflogenheiten. Die nächste Autorengeneration, die nur Schweiz, sondern überall aufmüpfiger war, konnte...

We hypothesized that decrements in maximum power output (W(max)) of the rat diaphragm (Dia) muscle with repetitive activation are due to a disproportionate reduction in force (force fatigue) compared with a slowing of shortening velocity (velocity fatigue). Segments of midcostal Dia muscle were mounted in vitro (26 degrees C) and stimulated directly at 75 Hz in 400-ms-duration trains repeated e...

Organophosphorus pesticides (OPs) are a public health concern due to their worldwide use and documented human exposures. Phosphorothioate OPs are metabolized by cytochrome P450s (P450s) through either a dearylation reaction to form an inactive metabolite, or through a desulfuration reaction to form an active oxon metabolite, which is a potent cholinesterase inhibitor. This study investigated th...

new insights through the quantitative description of regulatory processes Sergio Rossell This thesis has been reviewed by: prof. dr. Abbreviations and symbols 2PG 2-phosphoglycerate 3PG 3-phosphoglycerate AA aminoacids synthesis pathways ACE acetaldehyde ADH alcohol dehydrogenase –E.C. 1.1.1.1 ALD fluctose bisphosphate aldolase –E.C. 4.1.2.13 BPG 1,3-bisphosphoglycerate C J ei flux control coef...