Immunotherapy has drastically improved the survival prospect for advanced melanoma. Unfortunately, these treatments often come with cutaneous side effects which may cause patient to discontinue or delay therapy. To understand mechanism of immunotoxicity in relation clinical presentation, we characterized symptom clusters by and histologic morphology, severity rating, transcriptional analyses pa...

BACKGROUND Increased cytoplasmic HuR expression has been noted in several cancer types, where it may contribute to the increased cyclooxygenase-2 (COX-2) expression observed during tumorigenesis and metastasis. METHODS To assess the correlation between COX-2 and HuR in oral squamous cell carcinoma (OSCC), the expression patterns of HuR and COX-2 were assessed via immunohistochemistry analyses...

We adopted a game-theoretic approach to studying competition in the software market that is dependent on the network effect, i.e., where the success of the software product is mainly affected by the size of its installed base. The primary goals of our research were: to provide insights into competition between a new entrant with a significant presence in foreign countries and a home-grown incum...

We report Very Large Telescope observations of 11 lensed quasars, designed to measure the redshifts of their lens galaxies. We successfully determined the redshifts for seven systems, five of which were previously unknown. The securely measured redshifts for the lensing galaxies are: HE0047−1756 z = 0.408; PMNJ0134−0931 z = 0.766; HE0230−2130 z = 0.522; HE0435−1223 z = 0.455; SDSS0924+021 z = 0...

OBJECTIVE To determine which particular depressive symptom scales, derived from three scales, predicted poorer prognosis in persons with acute coronary syndrome (ACS). METHODS Hospitalized ACS patients (n=408) completed questionnaires (depression, vital exhaustion). Mokken scaling derived unidimensional scales. Major cardiac events (cardiac mortality, ACS, unplanned revascularization) were as...

One hundred sixty-nine Zimbabwean women were studied to determine whether the use of intravaginal practices (cleaning with the fingers, wiping the vagina, and inserting traditional substances) are associated with disturbances of vaginal flora and acquisition of sexually transmitted diseases (STDs). Subjects were interviewed and received counseling and a pelvic examination at enrollment, 1 month...