Malignant germ cell tumors are rare tumors of the childhood accounting for less than 3 % of pediatric malignancies. Endodermal sinus tumor (EST) is the most common histologic subtype of malignant GCT. The vagina is an extremely rare site for GCTs [1]. They are usually diagnosed before 3 years of age. Historically, the approach to therapy has included radical surgical resection with adjuvant irr...

Management of thirteen cases of malignant ovarian germ cell tumours was reported. Of these, 5 (38%) were immature teratoma, 3 (23%) were endodermal sinus tumour, 1 (8%) was dysgerminoma and 4 (31%) were mixed germ cell tumour. Eight (61%) had stage I, 1 (8%) had stage II and 4 (31%) had stage III diseases. Six had unilateral salpingo-oophorectomy, 6 had total abdominal hysterectomy and bilatera...

Klieger C, Dvir R, Even-Sapir E, Lessing JB, Burstein Y, Grisaru D. Integrated F-fluorodeoxyglucose positron emission tomography and computerized tomography in endodermal sinus tumor. Int J Gynecol Cancer 2006;16:1685–1688. Application of an in-line positron emission tomography and computerized tomography (PET-CT) in endodermal sinus tumor (EST) is described in this study. Case 1: A young femal...

Normal mesenchymal cells, normal epithelial cells and many transformed epithelial cells require serum attachment factors and extracellular matrix proteins for growth and differentiation in vitro, and recent evidence strongly supports a role for extracellular matrix molecules in the regulation of cell movement in vivo during early embryogenesis. We previously described the isolation and characte...