Effects of stimulating the left thoracic vagus nerve on the responses of spinothalamic neurons to electrical stimulation of cardiopulmonary sympathetic afferent fibers and to intracardiac injections of bradykinin were determined. Experiments were performed on 39 monkeys (Macaca fascicularis) tranquilized with ketamine and anesthetized with alpha-chloralose. The 30 spinothalamic cells studied ha...

BACKGROUND Although it has been shown that a vagus nerve stimulation of brain dead (BD) donors leads to an improvement of renal function in recipients in an acute allograft rejection model, its influence on chronic allograft nephropathy is still unknown. In the present study, we assessed the influence of donor vagus nerve stimulation on survival, renal function and histology in a chronic allogr...

BACKGROUND Recent clinical studies have shown that the dorsal motor nucleus of the vagus nerve is one of the brain areas that are the earliest affected by α-synuclein and Lewy body pathology in Parkinson's disease. This observation raises the question: how the vagus nerve dysfunction affects the dopamine system in the brain? METHODS The rats underwent surgical implantation of the microchip (M...

Background: Stroke is the leading cause of adult death in China and worldwide, characterized by high morbidity, disability, mortality, recurrence economic burden, often to various functional impairments, such as motor impairment, sensory swallowing consciousness impairment cognitive impairment. Therefore, finding effective intervention methods currently a hot difficult issue stroke rehab...

Because the vagus nerve is implicated in control of inflammation, we investigated if brain death (BD) causes impairment of the parasympathetic nervous system, thereby contributing to inflammation. BD was induced in rats. Anaesthetised ventilated rats (NBD) served as control. Heart rate variability (HRV) was assessed by ECG. The vagus nerve was electrically stimulated (BD + STIM) during BD. Inte...

................................................................................................................ ii List of Figures ..................................................................................................... viii List of Tables ....................................................................................................... xi CHAPTER 1: INTRODUCTION ...............

OBJECTIVE To describe the mechanism and first results of vagus nerve stimulation at the Medisch Spectrum Twenty, the Netherlands, for the treatment of patients with drug-resistant epilepsy. DESIGN Descriptive retrospective. METHOD Fifteen patients, 8 male and 7 female, aged 18-45 years with drug-resistant epilepsy, who were not eligible for surgical resection of an epileptic focus, received...

Auricular therapies have been applied to diseases since ancient times. Inspired by auricular acupuncture of TCM, and to overcome the disadvantages classic vagus nerve stimulation (VNS), we developed transcutaneous auricular vagus nerve stimulation (taVNS). It was applied to neurological and mental disorders, and also shows a bright prospect to these diseases.

The article provides an overview of key studies on vagus nerve stimulation. stimulation method affects the fibers internal and external plexuses, enhancing parasympathetic effect. positive therapeutic effect has been achieved in various experimental clinical treatment neurological cardiac diseases, metabolic syndrome, obesity. It shown that reduces epileptic seizures frequency, arrhythmias, is ...

Abstract Vagus nerve stimulation (VNS) activates vagal fibers to modulate organ function and treat conditions. VNS is currently delivered in a non-selective manner, often resulting reduced efficacy side effects. Development of selective therapies requires knowledge the anatomical organization inside vagus nerve. Motor sensory travel fascicles form branches innervate different organs, including ...