نتایج جستجو برای: valacyclovir
تعداد نتایج: 519 فیلتر نتایج به سال:
The possible involvement of herpesviruses in the pathogenesis of multiple sclerosis (MS) was recently investigated in a clinical trial of valacyclovir in patients with MS. As an important part of that survey we performed an independent pharmacokinetic study in order to determine the concentration of acyclovir in cerebrospinal fluid (CSF). The concentrations of acyclovir in serum and CSF were me...
OBJECTIVES/HYPOTHESIS We investigated how study design affects the rate of recovery in Bell's palsy. STUDY DESIGN Prospective, randomized, double-blind, placebo-controlled, multicenter trial. METHODS Data were extracted from the Scandinavian Bell's palsy study, which included 829 patients. The study design was factorial; 416 patients given prednisolone, 413 not given prednisolone, 413 patie...
BACKGROUND Herpes simplex virus type 2 (HSV-2) infection is common among human immunodeficiency virus (HIV)-infected persons, and HSV reactivation increases plasma and genital HIV-1 levels. We studied HIV-1 levels during HSV suppression in coinfected persons in a placebo-controlled crossover trial. METHODS Twenty antiretroviral therapy (ART)-naive HIV-1/HSV-2-seropositive men who have sex wit...
Recent in vitro studies suggest that acyclovir may directly inhibit HIV-1 replication and can select for a specific HIV-1 reverse transcriptase mutation (V75I) with concomitant loss of an anti-HIV-1 effect. We tested for HIV-1 genotypic resistance at reverse transcriptase codon 75 in plasma from 168 HIV-1-infected persons from Botswana, Kenya, Peru, and the United States taking daily acyclovir ...
Valacyclovir, a prodrug of acyclovir, may cause adverse drug reactions, so called acyclovir encephalopathy. The encephalopathy not be explained simply by blood concentrations, because recent reports suggest the involvement 9-carboxymethoxymethylguanine (CMMG), major metabolite acyclovir. present study demonstrates changes in serum concentrations and CMMG patient with suspected A 63-year-old mal...
Objective: The objective of the present work was to formulate a gastroretentive dosage form of Valacyclovir, an anti viral drug. Methods: Valacyclovir gastroretentive mucoadhesive tablets were prepared using polymers such as Carbopol 974P and hydroxy propyl methyl cellulose (HPMC) K4M, in different proportions by wet granulation technique. Compatibility studies were performed by FTIR spectrosco...
AIMS To compare the efficacy, costs and safety of oral ganciclovir and valacyclovir in the prophylaxis of cytomegalovirus (CMV) disease in renal transplant (RTx) recipients at high risk of CMV disease. METHODS A total of 83 patients were prospectively randomized to 3-month treatment with either oral ganciclovir (3 g/day) or oral valacyclovir (8 g/day). A 3rd group received no prophylaxis. For...
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