BACKGROUND/AIMS Available data about reflux patterns and symptom determinants in the gastroesophageal reflux disease (GERD) subtypes off proton pump inhibitor (PPI) therapy are lacking. We aimed to evaluate reflux patterns and determinants of symptom perception in patients with GERD off PPI therapy by impedance-pH monitoring. METHODS We retrospectively reviewed the impedance-pH data in patien...

BACKGROUND AND AIM The reason that some reflux episodes evoke symptoms is poorly understood, therefore the aim of this study is to assess the determinants of reflux perception in patients with non-erosive reflux disease (NERD) on proton pump inhibitor (PPI) therapy. METHODS Ten NERD patients with persistent symptoms, despite double-dose PPI therapy, were included in this study. All patients h...

Aortic valve stenosis is a heart disease prevalent in the elderly characterized by valvular calcification, fibrosis, and inflammation, but its exact pathogenesis remains unclear. Previously, aortic valve stenosis was thought to be caused by chronic passive and degenerative changes associated with aging. However, recent studies have demonstrated that atherosclerotic processes and inflammation ca...

Valvular tumor and tumor-like lesions are rare. Fibroelastoma is the most common valvular tumor, followed by myxoma. Atypical valvular lesions, such as organized thrombus, valvular calcification and valvular abscess may develop symptoms and present morphological features similar to those of the valvular tumors. The Author here reports a case of a tumour or tumourlike lesion over the mitral valv...

background gastroesophageal reflux disease is a common, chronic disease worldwide. the weekly prevalence of reflux in developed countries is 10% to 48%. it has previously been reported as 5% in asian countries, but new reports show a higher level in both asian and arab countries. in iran, reflux has increased over the last two decades. there are few studies concerning the prevalence of reflux i...

Atrial fibrillation, a chronic and highly morbid cardiovascular condition which affects over 33 million people worldwide, can be broadly categorized as valvular vs non-valvular in etiology. However, definitions of valvular atrial fibrillation have varied widely in the literature, and there is no clear consensus definition to date. Historically, patients with atrial fibrillation in the setting o...

BACKGROUND/AIMS There are no data concerning renal function in population with valvular and non-valvular atrial fibrillation (AF). To assess renal function in patients with AF, the association between eGFR and AF perpetuation, in-hospital mortality. METHODS We studied 1523 patients with AF. Patients with chronic kidney disease (CKD) were compared to population with preserved renal function. ...

abo and rh blood groups were studied in a total of 1680 patients with cardiovascular diseases (congenital n=547, valvular n=887 and coronary n=246). statistical analysis (x2and woolf’s test) showed significant excess of b/o in mitral valve, aortic valve total valvular diseases and heart diseases generally, also an increase of a/o in myocardial infarction. significant increase of the frequency o...

Non-erosive reflux disease (NERD) is the most common presentation of gastroesophageal reflux disease. Although acid reflux is the most important cause of symptom generation in NERD patients, non-acid reflux is also associated with reflux symptoms. The temporal relation between symptoms and reflux episodes is of importance in evaluating the results of combined pH-impedance monitoring in NERD pat...

Objective- Trigonella foenum graecum, (Fenugreek) has anti-inflammation, antiseptic and antidiabetic activities in traditional medicine. This study was performed to investigate the protection effects of Fenugreek seed extract on the experimental reflux esophigitis (RE) in rats. Design- experimental study. Animals- 24 male Wistar albino rats. Procedures- Rats were randomly allocated into 4 group...